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Development of a Model of Chronic Kidney Disease in the C57BL6 Mouse with Properties of Progressive Human CKD
المؤلفون المشاركون
Mohammed-Ali, Zahraa
Cruz, Gaile L.
Lu, Chao
Carlisle, Rachel E.
Werner, Kaitlyn E.
Ask, Kjetil
Dickhout, Jeffrey G.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-03
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Chronic kidney disease (CKD) is a major healthcare problem with increasing prevalence in the population.
CKD leads to end stage renal disease and increases the risk of cardiovascular disease.
As such, it is important to study the mechanisms underlying CKD progression.
To this end, an animal model was developed to allow the testing of new treatment strategies or molecular targets for CKD prevention.
Many underlying risk factors result in CKD but the disease itself has common features, including renal interstitial fibrosis, tubular epithelial cell loss through apoptosis, glomerular damage, and renal inflammation.
Further, CKD shows differences in prevalence between the genders with premenopausal women being relatively resistant to CKD.
We sought to develop and characterize an animal model with these common features of human CKD in the C57BL/6 mouse.
Mice of this genetic background have been used to produce transgenic strains that are commercially available.
Thus, a CKD model in this strain would allow the testing of the effects of numerous genes on the severity or progression of CKD with minimal cost.
This paper describes such a mouse model of CKD utilizing angiotensin II and deoxycorticosterone acetate as inducers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mohammed-Ali, Zahraa& Cruz, Gaile L.& Lu, Chao& Carlisle, Rachel E.& Werner, Kaitlyn E.& Ask, Kjetil…[et al.]. 2015. Development of a Model of Chronic Kidney Disease in the C57BL6 Mouse with Properties of Progressive Human CKD. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054489
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mohammed-Ali, Zahraa…[et al.]. Development of a Model of Chronic Kidney Disease in the C57BL6 Mouse with Properties of Progressive Human CKD. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1054489
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mohammed-Ali, Zahraa& Cruz, Gaile L.& Lu, Chao& Carlisle, Rachel E.& Werner, Kaitlyn E.& Ask, Kjetil…[et al.]. Development of a Model of Chronic Kidney Disease in the C57BL6 Mouse with Properties of Progressive Human CKD. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054489
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054489
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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