Immunosuppression and Multiple Primary Malignancies in Kidney-Transplanted Patients: A Single-Institute Study
المؤلفون المشاركون
Riccio, Eleonora
Santangelo, Michele L.
Criscitiello, Carmen
Renda, Andrea
Federico, Stefano
Curigliano, Giuseppe
Dodaro, Concetta
Scotti, Alessandro
Tammaro, Vincenzo
Calogero, Armando
Pisani, Antonio
Carlomagno, Nicola
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-22
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Immunodeficiency is associated with higher cancer incidence.
However, it is unknown whether there is a link between immunodeficiency and development of multiple primary malignancies.
In the present study we analyse this link focusing on kidney-transplanted patients, as they are at higher risk of developing cancer due to the chronic assumption of immunosuppressants.
We followed up 1200 patients who underwent kidney transplantation between 1980 and 2012.
A total of 77/1200 kidney-transplanted patients developed cancer and 24 of them developed multiple cancers.
Most multiple cancers were synchronous with a nonsignificant association between cancer and rejection episodes.
In the general cancer population, one-ninth of patients are at higher risk of developing a second tumor over a lifetime; hence it would be reasonable to conclude that, from a merely theoretical and statistical viewpoint, long-term transplanted patients potentially have a higher risk of developing MPMs.
However, data did not confirm this assumption, probably because these patients die before a second primary malignancy appears.
Despite many observations on the increased incidence of different tumor types in immunodeficient patients and despite immunosuppression certainly being a predisposing factor for the multicancer syndrome, data so far are not robust enough to justify a correlation between immunodeficiency and multiple primary malignancies in transplanted patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Santangelo, Michele L.& Criscitiello, Carmen& Renda, Andrea& Federico, Stefano& Curigliano, Giuseppe& Dodaro, Concetta…[et al.]. 2015. Immunosuppression and Multiple Primary Malignancies in Kidney-Transplanted Patients: A Single-Institute Study. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054530
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Santangelo, Michele L.…[et al.]. Immunosuppression and Multiple Primary Malignancies in Kidney-Transplanted Patients: A Single-Institute Study. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1054530
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Santangelo, Michele L.& Criscitiello, Carmen& Renda, Andrea& Federico, Stefano& Curigliano, Giuseppe& Dodaro, Concetta…[et al.]. Immunosuppression and Multiple Primary Malignancies in Kidney-Transplanted Patients: A Single-Institute Study. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054530
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054530
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر