Biomarker Identification and Pathway Analysis by Serum Metabolomics of Lung Cancer
المؤلفون المشاركون
Chen, Yingrong
Ma, Zhihong
Min, Lishan
Li, Hongwei
Wang, Bin
Zhong, Jing
Dai, Licheng
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-16
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Lung cancer is one of the most common causes of cancer death, for which no validated tumor biomarker is sufficiently accurate to be useful for diagnosis.
Additionally, the metabolic alterations associated with the disease are unclear.
In this study, we investigated the construction, interaction, and pathways of potential lung cancer biomarkers using metabolomics pathway analysis based on the Kyoto Encyclopedia of Genes and Genomes database and the Human Metabolome Database to identify the top altered pathways for analysis and visualization.
We constructed a diagnostic model using potential serum biomarkers from patients with lung cancer.
We assessed their specificity and sensitivity according to the area under the curve of the receiver operator characteristic (ROC) curves, which could be used to distinguish patients with lung cancer from normal subjects.
The pathway analysis indicated that sphingolipid metabolism was the top altered pathway in lung cancer.
ROC curve analysis indicated that glycerophospho-N-arachidonoyl ethanolamine (GpAEA) and sphingosine were potential sensitive and specific biomarkers for lung cancer diagnosis and prognosis.
Compared with the traditional lung cancer diagnostic biomarkers carcinoembryonic antigen and cytokeratin 19 fragment, GpAEA and sphingosine were as good or more appropriate for detecting lung cancer.
We report our identification of potential metabolic diagnostic and prognostic biomarkers of lung cancer and clarify the metabolic alterations in lung cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Yingrong& Ma, Zhihong& Min, Lishan& Li, Hongwei& Wang, Bin& Zhong, Jing…[et al.]. 2015. Biomarker Identification and Pathway Analysis by Serum Metabolomics of Lung Cancer. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054533
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Yingrong…[et al.]. Biomarker Identification and Pathway Analysis by Serum Metabolomics of Lung Cancer. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054533
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Yingrong& Ma, Zhihong& Min, Lishan& Li, Hongwei& Wang, Bin& Zhong, Jing…[et al.]. Biomarker Identification and Pathway Analysis by Serum Metabolomics of Lung Cancer. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054533
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054533
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر