Genetic Association between Methylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Osteonecrosis of the Femoral Head
المؤلفون المشاركون
Chai, Wei
Zhang, Zhendong
Ni, Ming
Geng, Peiliang
Lian, Zijian
Zhang, Guoqiang
Shi, Lewis L.
Chen, Jiying
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-26
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Methylenetetrahydrofolate reductase (MTHFR) SNP rs1801133 has been frequently investigated in recent years.
Relevant candidate gene association studies with this SNP and osteonecrosis of the femoral head (ONFH) reported conflicting results.
Meta-analysis provides a method to combine these data and to determine the association in a larger sample size.
Method.
We conducted a systematic search to identify possible studies.
Four pooled ORs (odds ratios, T versus C, TT versus CC, TT/CT versus CC, and TT versus CT/CC), along with 95% confidence interval (CI), were calculated to evaluate the association between SNP rs1801133 and ONFH susceptibility.
Both fixed effects model and random effects model were used.
Findings.
We eventually included twelve studies in this analysis, with results showing no overall association between ONFH susceptibility and SNP rs1801133 (T versus C: OR=1.15, 95% CI=0.97–1.38; TT versus CC: OR=1.15, 95% CI=0.91–1.46; TT/CT versus CC: OR=1.09, 95% CI=0.95–1.25; and TT versus CT/CC: OR=1.16, 95% CI=0.93–1.45).
When stratified based on ethnicity, the results were still not significant.
Conclusion.
Our findings are generally supportive of no association between MTHFR SNP rs1801133 and the etiology of ONFH.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chai, Wei& Zhang, Zhendong& Ni, Ming& Geng, Peiliang& Lian, Zijian& Zhang, Guoqiang…[et al.]. 2015. Genetic Association between Methylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Osteonecrosis of the Femoral Head. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054590
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chai, Wei…[et al.]. Genetic Association between Methylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Osteonecrosis of the Femoral Head. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1054590
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chai, Wei& Zhang, Zhendong& Ni, Ming& Geng, Peiliang& Lian, Zijian& Zhang, Guoqiang…[et al.]. Genetic Association between Methylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Osteonecrosis of the Femoral Head. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054590
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054590
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر