A Therapeutic Strategy for Spinal Cord Defect: Human Dental Follicle Cells Combined with Aligned PCLPLGA Electrospun Material

المؤلفون المشاركون

Li, Xinghan
Yang, Chao
Li, Lei
Xiong, Jie
Xie, Li
Yang, Bo
Yu, Mei
Feng, Lian
Jiang, Zongting
Guo, Weihua
Tian, Weidong

المصدر

BioMed Research International

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-01-28

دولة النشر

مصر

عدد الصفحات

12

التخصصات الرئيسية

الطب البشري

الملخص EN

Stem cell implantation has been utilized for the repair of spinal cord injury; however, it shows unsatisfactory performance in repairing large scale lesion of an organ.

We hypothesized that dental follicle cells (DFCs), which possess multipotential capability, could reconstruct spinal cord defect (SCD) in combination with biomaterials.

In the present study, mesenchymal and neurogenic lineage characteristics of human DFCs (hDFCs) were identified.

Aligned electrospun PCL/PLGA material (AEM) was fabricated and it would not lead to cytotoxic reaction; furthermore, hDFCs could stretch along the oriented fibers and proliferate efficiently on AEM.

Subsequently, hDFCs seeded AEM was transplanted to restore the defect in rat spinal cord.

Functional observation was performed but results showed no statistical significance.

The following histologic analyses proved that AEM allowed nerve fibers to pass through, and implanted hDFCs could express oligodendrogenic lineage maker Olig2 in vivo which was able to contribute to remyelination.

Therefore, we concluded that hDFCs can be a candidate resource in neural regeneration.

Aligned electrospun fibers can support spinal cord structure and induce cell/tissue polarity.

This strategy can be considered as alternative proposals for the SCD regeneration studies.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Li, Xinghan& Yang, Chao& Li, Lei& Xiong, Jie& Xie, Li& Yang, Bo…[et al.]. 2015. A Therapeutic Strategy for Spinal Cord Defect: Human Dental Follicle Cells Combined with Aligned PCLPLGA Electrospun Material. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1054594

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Li, Xinghan…[et al.]. A Therapeutic Strategy for Spinal Cord Defect: Human Dental Follicle Cells Combined with Aligned PCLPLGA Electrospun Material. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1054594

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Li, Xinghan& Yang, Chao& Li, Lei& Xiong, Jie& Xie, Li& Yang, Bo…[et al.]. A Therapeutic Strategy for Spinal Cord Defect: Human Dental Follicle Cells Combined with Aligned PCLPLGA Electrospun Material. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1054594

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1054594