Intratracheal Bleomycin Aerosolization: The Best Route of Administration for a Scalable and Homogeneous Pulmonary Fibrosis Rat Model?
المؤلفون المشاركون
Legrand, Alexandre
Robbe, Alexandre
Tassin, Alexandra
Carpentier, Justine
Declèves, Anne-Emilie
Mekinda Ngono, Zita Léa
Nonclercq, Denis
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-03
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Idiopathic pulmonary fibrosis (IPF) is a chronic disease with a poor prognosis and is characterized by the accumulation of fibrotic tissue in lungs resulting from a dysfunction in the healing process.
In humans, the pathological process is patchy and temporally heterogeneous and the exact mechanisms remain poorly understood.
Different animal models were thus developed.
Among these, intratracheal administration of bleomycin (BML) is one of the most frequently used methods to induce lung fibrosis in rodents.
In the present study, we first characterized histologically the time-course of lung alteration in rats submitted to BLM instillation.
Heterogeneous damages were observed among lungs, consisting in an inflammatory phase at early time-points.
It was followed by a transition to a fibrotic state characterized by an increased myofibroblast number and collagen accumulation.
We then compared instillation and aerosolization routes of BLM administration.
The fibrotic process was studied in each pulmonary lobe using a modified Ashcroft scale.
The two quantification methods were confronted and the interobserver variability evaluated.
Both methods induced fibrosis development as demonstrated by a similar progression of the highest modified Ashcroft score.
However, we highlighted that aerosolization allows a more homogeneous distribution of lesions among lungs, with a persistence of higher grade damages upon time.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Robbe, Alexandre& Tassin, Alexandra& Carpentier, Justine& Declèves, Anne-Emilie& Mekinda Ngono, Zita Léa& Nonclercq, Denis…[et al.]. 2015. Intratracheal Bleomycin Aerosolization: The Best Route of Administration for a Scalable and Homogeneous Pulmonary Fibrosis Rat Model?. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054604
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Robbe, Alexandre…[et al.]. Intratracheal Bleomycin Aerosolization: The Best Route of Administration for a Scalable and Homogeneous Pulmonary Fibrosis Rat Model?. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1054604
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Robbe, Alexandre& Tassin, Alexandra& Carpentier, Justine& Declèves, Anne-Emilie& Mekinda Ngono, Zita Léa& Nonclercq, Denis…[et al.]. Intratracheal Bleomycin Aerosolization: The Best Route of Administration for a Scalable and Homogeneous Pulmonary Fibrosis Rat Model?. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054604
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054604
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر