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Left Atrial Appendage: Physiology, Pathology, and Role as a Therapeutic Target
المؤلفون المشاركون
Agricola, Eustachio
Regazzoli, Damiano
Ancona, Francesco
Trevisi, Nicola
Guarracini, Fabrizio
Radinovic, Andrea
Oppizzi, Michele
Marzi, Alessandra
Sora, Nicoleta Carmen
Della Bella, Paolo
Mazzone, Patrizio
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-07
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Atrial fibrillation (AF) is the most common clinically relevant cardiac arrhythmia.
AF poses patients at increased risk of thromboembolism, in particular ischemic stroke.
The CHADS2 and CHA2DS2-VASc scores are useful in the assessment of thromboembolic risk in nonvalvular AF and are utilized in decision-making about treatment with oral anticoagulation (OAC).
However, OAC is underutilized due to poor patient compliance and contraindications, especially major bleedings.
The Virchow triad synthesizes the pathogenesis of thrombogenesis in AF: endocardial dysfunction, abnormal blood stasis, and altered hemostasis.
This is especially prominent in the left atrial appendage (LAA), where the low flow reaches its minimum.
The LAA is the remnant of the embryonic left atrium, with a complex and variable morphology predisposing to stasis, especially during AF.
In patients with nonvalvular AF, 90% of thrombi are located in the LAA.
So, left atrial appendage occlusion could be an interesting and effective procedure in thromboembolism prevention in AF.
After exclusion of LAA as an embolic source, the remaining risk of thromboembolism does not longer justify the use of oral anticoagulants.
Various surgical and catheter-based methods have been developed to exclude the LAA.
This paper reviews the physiological and pathophysiological role of the LAA and catheter-based methods of LAA exclusion.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Regazzoli, Damiano& Ancona, Francesco& Trevisi, Nicola& Guarracini, Fabrizio& Radinovic, Andrea& Oppizzi, Michele…[et al.]. 2015. Left Atrial Appendage: Physiology, Pathology, and Role as a Therapeutic Target. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1054624
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Regazzoli, Damiano…[et al.]. Left Atrial Appendage: Physiology, Pathology, and Role as a Therapeutic Target. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1054624
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Regazzoli, Damiano& Ancona, Francesco& Trevisi, Nicola& Guarracini, Fabrizio& Radinovic, Andrea& Oppizzi, Michele…[et al.]. Left Atrial Appendage: Physiology, Pathology, and Role as a Therapeutic Target. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1054624
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054624
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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