![](/images/graphics-bg.png)
Antiherpes Activity and SkinMucosa Distribution of Flavonoids from Achyrocline satureioides Extract Incorporated into Topical Nanoemulsions
المؤلفون المشاركون
Bidone, Juliana
Argenta, Débora Fretes
Kratz, Jadel
Pettenuzzo, Letícia Ferreira
Horn, Ana Paula
Koester, Letícia Scherer
Bassani, Valquíria Linck
Simões, Claudia Maria Oliveira
Teixeira, Helder Ferreira
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-25
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
This study investigated the inhibitory effects of Achyrocline satureioides extract (ASE) incorporated into a topical nanoemulsion on Herpes Simplex Virus type 1 (HSV-1/KOS strain) replication, as well as the distribution of the main ASE flavonoids (quercetin, luteolin, and 3-O-methylquercetin) in porcine skin and mucosa.
The ASE-loaded nanoemulsion showed more pronounced effects against HSV-1 replication when compared to the ASE or pure quercetin, as determined by the viral plaque number reduction assay.
All flavonoids were detected in the skin epidermis (2.2 µg/cm2) and the mucosa upper layers (3.0 µg/cm2) from ASE-loaded nanoemulsion until 8 h after topical application.
A higher amount of flavonoids was detected when these tissues were impaired, especially in deeper mucosa layers (up to 7-fold).
Flavonoids were detected in the receptor fluid only when the mucosa was injured.
Such results were supported by confocal microscopy images.
Overall, these findings suggest that the tested ASE-loaded nanoemulsion has potential to be used topically for herpes infections.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bidone, Juliana& Argenta, Débora Fretes& Kratz, Jadel& Pettenuzzo, Letícia Ferreira& Horn, Ana Paula& Koester, Letícia Scherer…[et al.]. 2015. Antiherpes Activity and SkinMucosa Distribution of Flavonoids from Achyrocline satureioides Extract Incorporated into Topical Nanoemulsions. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054702
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bidone, Juliana…[et al.]. Antiherpes Activity and SkinMucosa Distribution of Flavonoids from Achyrocline satureioides Extract Incorporated into Topical Nanoemulsions. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054702
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bidone, Juliana& Argenta, Débora Fretes& Kratz, Jadel& Pettenuzzo, Letícia Ferreira& Horn, Ana Paula& Koester, Letícia Scherer…[et al.]. Antiherpes Activity and SkinMucosa Distribution of Flavonoids from Achyrocline satureioides Extract Incorporated into Topical Nanoemulsions. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054702
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054702
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)