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Functional Alteration of Natural Killer Cells and Cytotoxic T Lymphocytes upon Asbestos Exposure and in Malignant Mesothelioma Patients
المؤلفون المشاركون
Lee, Suni
Maeda, Megumi
Otsuki, Takemi
Kishimoto, Takumi
Nakano, Takashi
Fukuoka, Kazuya
Nishimura, Yasumitsu
Matsuzaki, Hidenori
Kumagai-Takei, Naoko
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-16
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Malignant mesothelioma is caused by exposure to asbestos, which is known to have carcinogenic effects.
However, the development of mesothelioma takes a long period and results from a low or intermediate dose of exposure.
These findings have motivated us to investigate the immunological effects of asbestos exposure and analyze immune functions of patients with mesothelioma and pleural plaque, a sign of exposure to asbestos.
Here, we review our knowledge concerning natural killer (NK) cells and cytotoxic T lymphocytes (CTL).
NK cells showed impaired cytotoxicity with altered expression of activating receptors upon exposure to asbestos, while induction of granzyme+ cells in CD8+ lymphocytes was suppressed by asbestos exposure.
It is interesting that a decrease in NKp46, a representative activating receptor, is common between NK cells in PBMC culture with asbestos and those of mesothelioma patients.
Moreover, it was observed that CD8+ lymphocytes may be stimulated by some kind of “nonself” cells in plaque-positive individuals and in mesothelioma patients, whereas CTL in mesothelioma is impaired by poststimulation maintenance of cytotoxicity.
These findings suggest that analysis of immunological parameters might contribute to the evaluation of health conditions of asbestos-exposed individuals and to a greater understanding of the pathology of malignant mesothelioma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nishimura, Yasumitsu& Kumagai-Takei, Naoko& Matsuzaki, Hidenori& Lee, Suni& Maeda, Megumi& Kishimoto, Takumi…[et al.]. 2015. Functional Alteration of Natural Killer Cells and Cytotoxic T Lymphocytes upon Asbestos Exposure and in Malignant Mesothelioma Patients. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054704
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nishimura, Yasumitsu…[et al.]. Functional Alteration of Natural Killer Cells and Cytotoxic T Lymphocytes upon Asbestos Exposure and in Malignant Mesothelioma Patients. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054704
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nishimura, Yasumitsu& Kumagai-Takei, Naoko& Matsuzaki, Hidenori& Lee, Suni& Maeda, Megumi& Kishimoto, Takumi…[et al.]. Functional Alteration of Natural Killer Cells and Cytotoxic T Lymphocytes upon Asbestos Exposure and in Malignant Mesothelioma Patients. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054704
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054704
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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