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Tissue Remodelling following Resection of Porcine Liver
المؤلفون المشاركون
Nygård, I. E.
Revhaug, A.
Mortensen, Kim Erlend
Hedegaard, Jakob
Conley, Lene Nagstrup
Bendixen, Christian
Sveinbjørnsson, Baldur
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-09
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Aim.
To study genes regulating the extracellular matrix (ECM) and investigate the tissue remodelling following liver resection in porcine.
Methods.
Four pigs with 60% partial hepatectomy- (PHx-) induced liver regeneration were studied over six weeks.
Four pigs underwent sham surgery and another four pigs were used as controls of the normal liver growth.
Liver biopsies were taken upon laparotomy, after three and six weeks.
Gene expression profiles were obtained using porcine-specific oligonucleotide microarrays.
Immunohistochemical staining was performed and a proliferative index was assessed.
Results.
More differentially expressed genes were associated with the regulation of ECM in the resection group compared to the sham and control groups.
Secreted protein acidic and rich in cysteine (SPARC) and collagen 1, alpha 2 (COL1A2) were both upregulated in the early phase of liver regeneration, validated by immunopositive cells during the remodelling phase of liver regeneration.
A broadened connective tissue was demonstrated by Masson’s Trichrome staining, and an immunohistochemical staining against pan-Cytokeratin (pan-CK) demonstrated a distinct pattern of migrating cells, followed by proliferating cell nuclear antigen (PCNA) positive nuclei.
Conclusions.
The present study demonstrates both a distinct pattern of PCNA positive nuclei and a deposition of ECM proteins in the remodelling phase of liver regeneration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nygård, I. E.& Mortensen, Kim Erlend& Hedegaard, Jakob& Conley, Lene Nagstrup& Bendixen, Christian& Sveinbjørnsson, Baldur…[et al.]. 2015. Tissue Remodelling following Resection of Porcine Liver. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054747
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nygård, I. E.…[et al.]. Tissue Remodelling following Resection of Porcine Liver. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1054747
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nygård, I. E.& Mortensen, Kim Erlend& Hedegaard, Jakob& Conley, Lene Nagstrup& Bendixen, Christian& Sveinbjørnsson, Baldur…[et al.]. Tissue Remodelling following Resection of Porcine Liver. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054747
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054747
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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