Effects of P-15 Peptide Coated Hydroxyapatite on Tibial Defect Repair In Vivo in Normal and Osteoporotic Rats

المؤلفون المشاركون

Hestehave Pedersen, Rasmus
Rasmussen, Marina
Overgaard, Søren
Ding, Ming

المصدر

BioMed Research International

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-14، 14ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-10-05

دولة النشر

مصر

عدد الصفحات

14

التخصصات الرئيسية

الطب البشري

الملخص EN

This study assessed the efficacy of anorganic bone mineral coated with P-15 peptide (ABM/P-15) on tibia defect repair longitudinally in both normal and osteoporotic rats in vivo.

A paired design was used.

24 Norwegian brown rats were divided into normal and osteoporotic groups.

48 cylindrical defects were created in proximal tibias bilaterally.

Defects were filled with ABM/P-15 or left empty.

Osteoporotic status was assessed by microarchitectural analysis.

Microarchitectural properties of proximal tibial defects were evaluated at 4 time points.

21 days after surgery, tibias were harvested for histology and histomorphometry.

Significantly increased bone volume fraction, surface density, and connectivity were seen in all groups at days 14 and 21 compared with day 0.

Moreover, the structure type of ABM/P-15 group was changed toward typical plate-like structure.

Microarchitectural properties of ABM/P-15 treated newly formed bones at 21 days were similar in normal and osteoporotic rats.

Histologically, significant bone formation was seen in all groups.

Interestingly, significantly increased bone formation was seen in osteoporotic rats treated with ABM/P-15 indicating optimized healing potential.

Empty defects showed lower healing potential in osteoporotic bone.

In conclusion, ABM/P-15 accelerated bone regeneration in osteoporotic rats but did not enhance bone regeneration in normal rats.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Hestehave Pedersen, Rasmus& Rasmussen, Marina& Overgaard, Søren& Ding, Ming. 2015. Effects of P-15 Peptide Coated Hydroxyapatite on Tibial Defect Repair In Vivo in Normal and Osteoporotic Rats. BioMed Research International،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1054762

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Hestehave Pedersen, Rasmus…[et al.]. Effects of P-15 Peptide Coated Hydroxyapatite on Tibial Defect Repair In Vivo in Normal and Osteoporotic Rats. BioMed Research International No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1054762

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Hestehave Pedersen, Rasmus& Rasmussen, Marina& Overgaard, Søren& Ding, Ming. Effects of P-15 Peptide Coated Hydroxyapatite on Tibial Defect Repair In Vivo in Normal and Osteoporotic Rats. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1054762

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1054762