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Thymoquinone-Loaded Nanostructured Lipid Carrier Exhibited Cytotoxicity towards Breast Cancer Cell Lines (MDA-MB-231 and MCF-7) and Cervical Cancer Cell Lines (HeLa and SiHa)
المؤلفون المشاركون
How, Chee Wun
Abdullah, Rasedee
Ng, Wei Keat
Saiful Yazan, Latifah
Yap, Li Hua
Wan Nor Hafiza, Wan Abd Ghani
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-06
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Thymoquinone (TQ) has been shown to exhibit antitumor properties.
Thymoquinone-loaded nanostructured lipid carrier (TQ-NLC) was developed to improve the bioavailability and cytotoxicity of TQ.
This study was conducted to determine the cytotoxic effects of TQ-NLC on breast cancer (MDA-MB-231 and MCF-7) and cervical cancer cell lines (HeLa and SiHa).
TQ-NLC was prepared by applying the hot high pressure homogenization technique.
The mean particle size of TQ-NLC was 35.66 ± 0.1235 nm with a narrow polydispersity index (PDI) lower than 0.25.
The zeta potential of TQ-NLC was greater than −30 mV.
Polysorbate 80 helps to increase the stability of TQ-NLC.
Differential scanning calorimetry showed that TQ-NLC has a melting point of 56.73°C, which is lower than that of the bulk material.
The encapsulation efficiency of TQ in TQ-NLC was 97.63 ± 0.1798% as determined by HPLC analysis.
TQ-NLC exhibited antiproliferative activity towards all the cell lines in a dose-dependent manner which was most cytotoxic towards MDA-MB-231 cells.
Cell shrinkage was noted following treatment of MDA-MB-231 cells with TQ-NLC with an increase of apoptotic cell population ( P < 0.05 ).
TQ-NLC also induced cell cycle arrest.
TQ-NLC was most cytotoxic towards MDA-MB-231 cells.
It induced apoptosis and cell cycle arrest in the cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ng, Wei Keat& Saiful Yazan, Latifah& Yap, Li Hua& Wan Nor Hafiza, Wan Abd Ghani& How, Chee Wun& Abdullah, Rasedee. 2015. Thymoquinone-Loaded Nanostructured Lipid Carrier Exhibited Cytotoxicity towards Breast Cancer Cell Lines (MDA-MB-231 and MCF-7) and Cervical Cancer Cell Lines (HeLa and SiHa). BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054806
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ng, Wei Keat…[et al.]. Thymoquinone-Loaded Nanostructured Lipid Carrier Exhibited Cytotoxicity towards Breast Cancer Cell Lines (MDA-MB-231 and MCF-7) and Cervical Cancer Cell Lines (HeLa and SiHa). BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1054806
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ng, Wei Keat& Saiful Yazan, Latifah& Yap, Li Hua& Wan Nor Hafiza, Wan Abd Ghani& How, Chee Wun& Abdullah, Rasedee. Thymoquinone-Loaded Nanostructured Lipid Carrier Exhibited Cytotoxicity towards Breast Cancer Cell Lines (MDA-MB-231 and MCF-7) and Cervical Cancer Cell Lines (HeLa and SiHa). BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054806
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054806
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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