Characterization of Closed Head Impact Injury in Rat

المؤلفون المشاركون

Hua, Yi
Akula, Praveen
Kelso, Matthew
Gu, Linxia

المصدر

BioMed Research International

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-09-16

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الطب البشري

الملخص EN

The closed head impact (CHI) rat models are commonly used for studying the traumatic brain injury.

The impact parameters vary considerably among different laboratories, making the comparison of research findings difficult.

In this work, numerical CHI experiments were conducted to investigate the sensitivities of intracranial responses to various impact parameters (e.g., impact depth, velocity, and position; impactor diameter, material, and shape).

A three-dimensional finite element rat head model with anatomical details was subjected to impact loadings.

Results revealed that impact depth and impactor shape were the two leading factors affecting intracranial responses.

The influence of impactor diameter was region-specific and an increase in impactor diameter could substantially increase tissue strains in the region which located directly beneath the impactor.

The lateral impact could induce higher strains in the brain than the central impact.

An indentation depth instead of impact depth would be appropriate to characterize the influence of a large deformed rubber impactor.

The experimentally observed velocity-dependent injury severity could be attributed to the “overshoot” phenomenon.

This work could be used to better design or compare CHI experiments.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Hua, Yi& Akula, Praveen& Kelso, Matthew& Gu, Linxia. 2015. Characterization of Closed Head Impact Injury in Rat. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054834

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Hua, Yi…[et al.]. Characterization of Closed Head Impact Injury in Rat. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054834

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Hua, Yi& Akula, Praveen& Kelso, Matthew& Gu, Linxia. Characterization of Closed Head Impact Injury in Rat. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054834

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1054834