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Cinnabar-Induced Subchronic Renal Injury Is Associated with Increased Apoptosis in Rats
المؤلفون المشاركون
Wang, Ying
Wang, Dapeng
Wu, Jie
Wang, Bohan
Gao, Xianhui
Wang, Liangjun
Ma, Honglin
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-06
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The aim of this study was to explore the role of apoptosis in cinnabar-induced renal injury in rats.
To test this role, rats were dosed orally with cinnabar (1 g/kg/day) for 8 weeks or 12 weeks, and the control rats were treated with 5% carboxymethylcellulose solution.
Levels of urinary mercury (UHg), renal mercury (RHg), serum creatinine (SCr), and urine kidney injury molecule 1 (KIM-1) were assessed, and renal pathology was analyzed.
Apoptotic cells were identified and the apoptotic index was calculated.
A rat antibody array was used to analyze expression of cytokines associated with apoptosis.
Results from these analyses showed that UHg, RHg, and urine KIM-1, but not SCr, levels were significantly increased in cinnabar-treated rats.
Renal pathological changes in cinnabar-treated rats included vacuolization of tubular cells, formation of protein casts, infiltration of inflammatory cells, and increase in the number of apoptotic tubular cells.
In comparison to the control group, expression of FasL, Fas, TNF- α, TRAIL, activin A, and adiponectin was upregulated in the cinnabar-treated group.
Collectively, our results suggest that prolonged use of cinnabar results in kidney damage due to accumulation of mercury and that the underlying mechanism involves apoptosis of tubular cells via a death receptor-mediated pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Ying& Wang, Dapeng& Wu, Jie& Wang, Bohan& Gao, Xianhui& Wang, Liangjun…[et al.]. 2015. Cinnabar-Induced Subchronic Renal Injury Is Associated with Increased Apoptosis in Rats. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054852
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Ying…[et al.]. Cinnabar-Induced Subchronic Renal Injury Is Associated with Increased Apoptosis in Rats. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1054852
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Ying& Wang, Dapeng& Wu, Jie& Wang, Bohan& Gao, Xianhui& Wang, Liangjun…[et al.]. Cinnabar-Induced Subchronic Renal Injury Is Associated with Increased Apoptosis in Rats. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054852
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054852
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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