Systematic Analysis and Prediction of In Situ Cross Talk of O-GlcNAcylation and Phosphorylation
المؤلفون المشاركون
Yao, Heming
Li, Ao
Wang, Minghui
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-27
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Reversible posttranslational modification (PTM) plays a very important role in biological process by changing properties of proteins.
As many proteins are multiply modified by PTMs, cross talk of PTMs is becoming an intriguing topic and draws much attention.
Currently, lots of evidences suggest that the PTMs work together to accomplish a specific biological function.
However, both the general principles and underlying mechanism of PTM crosstalk are elusive.
In this study, by using large-scale datasets we performed evolutionary conservation analysis, gene ontology enrichment, motif extraction of proteins with cross talk of O-GlcNAcylation and phosphorylation cooccurring on the same residue.
We found that proteins with in situ O-GlcNAc/Phos cross talk were significantly enriched in some specific gene ontology terms and no obvious evolutionary pressure was observed.
Moreover, 3 functional motifs associated with O-GlcNAc/Phos sites were extracted.
We further used sequence features and GO features to predict O-GlcNAc/Phos cross talk sites based on phosphorylated sites and O-GlcNAcylated sites separately by the use of SVM model.
The AUC of classifier based on phosphorylated sites is 0.896 and the other classifier based on GlcNAcylated sites is 0.843.
Both classifiers achieved a relatively better performance compared with other existing methods.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yao, Heming& Li, Ao& Wang, Minghui. 2015. Systematic Analysis and Prediction of In Situ Cross Talk of O-GlcNAcylation and Phosphorylation. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1054856
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yao, Heming…[et al.]. Systematic Analysis and Prediction of In Situ Cross Talk of O-GlcNAcylation and Phosphorylation. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1054856
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yao, Heming& Li, Ao& Wang, Minghui. Systematic Analysis and Prediction of In Situ Cross Talk of O-GlcNAcylation and Phosphorylation. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1054856
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054856
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر