Ocular Manifestations and Therapeutic Options in Patients with Familial Amyloid Polyneuropathy: A Systematic Review
المؤلفون المشاركون
Rosa, Andreia Martins
Murta, Joaquim
Martins, A. C.
Costa, E.
Tavares, C.
Quadrado, M. J.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-19
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Purpose.
This paper aims to review the morphological and functional characteristics of patients affected by familial amyloid polyneuropathy (FAP), with greater focus on type I and its progression after liver transplantation.
We also analyse therapeutic options for the ophthalmic manifestations.
Methods.
The literature from 2002 through 2015 was reviewed, with a total of 45 articles studied, using the key terms related to amyloidosis and its therapeutic approaches.
Information was collated, evaluated, critically assessed, and then summarised in its present form.
Pathophysiology and Treatment.
FAP results from mutation of the transthyretin gene, with Val30Met being the most frequent substitution.
The symptoms are those typical of a sensorimotor autonomic neuropathy and can be halted with liver transplantation.
Nowadays there are new medical therapies that delay the progression of the systemic neuropathy.
However, there are still no options to avoid ocular disease.
Conclusion.
The main ocular manifestations in patients with FAP type I are amyloid deposition in the vitreous, dry eye, and secondary glaucoma.
Despite liver transplantation, eye synthesis of amyloid persists and is associated with progressive ocular manifestations, which require continued ophthalmologic follow-up.
New therapeutic strategies are therefore needed, particularly to target the ocular synthesis of the abnormal protein.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Martins, A. C.& Rosa, Andreia Martins& Costa, E.& Tavares, C.& Quadrado, M. J.& Murta, Joaquim. 2015. Ocular Manifestations and Therapeutic Options in Patients with Familial Amyloid Polyneuropathy: A Systematic Review. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054873
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Martins, A. C.…[et al.]. Ocular Manifestations and Therapeutic Options in Patients with Familial Amyloid Polyneuropathy: A Systematic Review. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054873
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Martins, A. C.& Rosa, Andreia Martins& Costa, E.& Tavares, C.& Quadrado, M. J.& Murta, Joaquim. Ocular Manifestations and Therapeutic Options in Patients with Familial Amyloid Polyneuropathy: A Systematic Review. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054873
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054873
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر