Zearalenone Inhibits Rat and Human 11β-Hydroxysteroid Dehydrogenase Type 2

المؤلفون المشاركون

Ge, Ren-Shan
Li, Linxi
Wu, Xiaolong
Guan, Hongguo
Mao, Baiping
Wang, Huang
Yuan, Xiaohuan
Chu, Yanhui
Sun, Jianliang

المصدر

BioMed Research International

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-12-20

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الطب البشري

الملخص EN

Zearalenone is a mycotoxin produced by Fusarium spp.

11β-Hydroxysteroid dehydrogenases, isoforms 1 (HSD11B1) and 2 (HSD11B2), have been demonstrated to be the regulators of the local level of active glucocorticoid, which has a broad range of physiological actions.

In the present study, the potency of zearalenone was tested for the inhibition of HSD11B1 and HSD11B2 in rat and human tissues.

Zearalenone showed potent inhibition of HSD11B2 with the half-maximal inhibitory concentration (IC50) calculated at 49.63 and 32.22 μM for the rat and human, respectively.

Results showed that zearalenone competitively inhibited HSD11B2 when a steroid substrate was used.

However, it served as an uncompetitive inhibitory factor when the cofactor NAD+ was used.

In contrast, the potency of zearalenone to inhibit both rat and human HSD11B1 was diminished, with the concentration of 100 μM causing almost no inhibitory effect on the isoform.

In conclusion, we observed that zearalenone is a selective inhibitor of HSD11B2, implying that this agent may cause excessive glucocorticoid action in local tissues such as kidney and placentas.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Li, Linxi& Wu, Xiaolong& Guan, Hongguo& Mao, Baiping& Wang, Huang& Yuan, Xiaohuan…[et al.]. 2015. Zearalenone Inhibits Rat and Human 11β-Hydroxysteroid Dehydrogenase Type 2. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054877

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Li, Linxi…[et al.]. Zearalenone Inhibits Rat and Human 11β-Hydroxysteroid Dehydrogenase Type 2. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054877

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Li, Linxi& Wu, Xiaolong& Guan, Hongguo& Mao, Baiping& Wang, Huang& Yuan, Xiaohuan…[et al.]. Zearalenone Inhibits Rat and Human 11β-Hydroxysteroid Dehydrogenase Type 2. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054877

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1054877