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The 482Ser of PPARGC1A and 12Pro of PPARG2 Alleles Are Associated with Reduction of Metabolic Risk Factors Even Obesity in a Mexican-Mestizo Population
المؤلفون المشاركون
Navarro-Hernandez, Rosa Elena
Guzmán-Ornelas, Milton-Omar
Corona Meraz, Fernanda-Isadora
Ríos-Ibarra, Clara-Patricia
Reyes-Serratos, Eduardo-Alejandro
Castro-Albarran, Jorge
Ruíz-Quezada, Sandra-Luz
Vázquez-Del Mercado, Mónica
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-22
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
The aim of this study was to investigate the relationship between functional polymorphisms Gly482Ser in PPARGC1A and Pro12Ala in PPARG2 with the presence of obesity and metabolic risk factors.
We included 375 individuals characterized as Mexican-Mestizos and classified by the body mass index (BMI).
Body dimensions and distribution of body fat were measured.
The HOMA-IR and adiposity indexes were calculated.
Adipokines and metabolic profile quantification were performed by ELISA and routine methods.
Genetic polymorphisms were determined by polymerase chain reaction restriction fragment length polymorphism analysis.
A difference between obese and nonobese subjects in polymorphism PPARGC1A distribution was observed.
Among obese individuals, carriers of genotype 482Gly/Gly were observed to have decreased body fat, BMI, and body fat ratio versus 482Ser/Ser carriers and increased resistin and leptin levels in carriers Gly+ phenotype versus Gly− phenotype.
Subjects with PPARG2 Ala− phenotype (genotype 12Pro/Pro) showed a decreased HOMA-IR index versus individuals with Ala+ phenotype (genotypes 12Pro/Ala plus 12Ala/Ala).
We propose that, in obese Mexican-Mestizos, the combination of alleles 482Ser in PPARGC1A and 12Pro in PPARG2 represents a reduced metabolic risk profile, even when the adiposity indexes are increased.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vázquez-Del Mercado, Mónica& Guzmán-Ornelas, Milton-Omar& Corona Meraz, Fernanda-Isadora& Ríos-Ibarra, Clara-Patricia& Reyes-Serratos, Eduardo-Alejandro& Castro-Albarran, Jorge…[et al.]. 2015. The 482Ser of PPARGC1A and 12Pro of PPARG2 Alleles Are Associated with Reduction of Metabolic Risk Factors Even Obesity in a Mexican-Mestizo Population. BioMed Research International،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1054893
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vázquez-Del Mercado, Mónica…[et al.]. The 482Ser of PPARGC1A and 12Pro of PPARG2 Alleles Are Associated with Reduction of Metabolic Risk Factors Even Obesity in a Mexican-Mestizo Population. BioMed Research International No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1054893
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vázquez-Del Mercado, Mónica& Guzmán-Ornelas, Milton-Omar& Corona Meraz, Fernanda-Isadora& Ríos-Ibarra, Clara-Patricia& Reyes-Serratos, Eduardo-Alejandro& Castro-Albarran, Jorge…[et al.]. The 482Ser of PPARGC1A and 12Pro of PPARG2 Alleles Are Associated with Reduction of Metabolic Risk Factors Even Obesity in a Mexican-Mestizo Population. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1054893
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054893
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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