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Heterogeneity of Genetic Damage in Cervical Nuclei and Lymphocytes in Women with Different Levels of Dysplasia and Cancer-Associated Risk Factors
المؤلفون المشاركون
Alvarez-Moya, Carlos
Reynoso-Silva, Mónica
Canales-Aguirre, Alejandro A.
Chavez-Chavez, José O.
Castañeda-Vázquez, Hugo
Feria-Velasco, Alfredo I.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-03
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The comet assay can be used to assess genetic damage, but heterogeneity in the length of the tails is frequently observed.
The aims of this study were to evaluate genetic damage and heterogeneity in the cervical nuclei and lymphocytes from patients with different levels of dysplasia and to determine the risk factors associated with the development of cervical cancer.
The study included 97 females who presented with different levels of dysplasia.
A comet assay was performed in peripheral blood lymphocytes and cervical epithelial cells.
Significant genetic damage (P≤0.05) was observed only in patients diagnosed with nuclei cervical from dysplasia III (NCDIII) and lymphocytes from dysplasia I (LDI).
However, the standard deviations of the tail lengths in the cervical nuclei and lymphocytes from patients with dysplasia I were significantly different (P≤0.0001) from the standard deviations of the tail lengths in the nuclei cervical and lymphocytes from patients with DII and DIII (NCDII, NCDIII and LDII, LDIII), indicating a high heterogeneity in tail length.
Results suggest that genetic damage could be widely present but only manifested as increased tail length in certain cell populations.
This heterogeneity could obscure the statistical significance of the genetic damage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alvarez-Moya, Carlos& Reynoso-Silva, Mónica& Canales-Aguirre, Alejandro A.& Chavez-Chavez, José O.& Castañeda-Vázquez, Hugo& Feria-Velasco, Alfredo I.. 2015. Heterogeneity of Genetic Damage in Cervical Nuclei and Lymphocytes in Women with Different Levels of Dysplasia and Cancer-Associated Risk Factors. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054933
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alvarez-Moya, Carlos…[et al.]. Heterogeneity of Genetic Damage in Cervical Nuclei and Lymphocytes in Women with Different Levels of Dysplasia and Cancer-Associated Risk Factors. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1054933
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alvarez-Moya, Carlos& Reynoso-Silva, Mónica& Canales-Aguirre, Alejandro A.& Chavez-Chavez, José O.& Castañeda-Vázquez, Hugo& Feria-Velasco, Alfredo I.. Heterogeneity of Genetic Damage in Cervical Nuclei and Lymphocytes in Women with Different Levels of Dysplasia and Cancer-Associated Risk Factors. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054933
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054933
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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