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Motor Neuron Diseases in Sub-Saharan Africa: The Need for More Population-Based Studies
المؤلفون المشاركون
Quansah, Emmanuel
Karikari, Thomas K.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-12
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Motor neuron diseases (MNDs) are devastating neurological diseases that are characterised by gradual degeneration and death of motor neurons.
Major types of MNDs include amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA).
These diseases are incurable, with limited disease-modifying treatment options.
In order to improve MND-based biomedical research, drug development, and clinical care, population-based studies will be important.
These studies, especially among less-studied populations, might identify novel factors controlling disease susceptibility and resistance.
To evaluate progress in MND research in Africa, we examined the published literature on MNDs in Sub-Saharan Africa to identify disease prevalence, genetic factors, and other risk factors.
Our findings indicate that the amount of research evidence on MNDs in Sub-Saharan Africa is scanty; molecular and genetics-based studies are particularly lacking.
While only a few genetic studies were identified, these studies strongly suggest that there appear to be population-specific causes of MNDs among Africans.
MND genetic underpinnings vary among different African populations and also between African and non-African populations.
Further studies, especially molecular, genetic and genomic studies, will be required to advance our understanding of MND biology among African populations.
Insights from these studies would help to improve the timeliness and accuracy of clinical diagnosis and treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Quansah, Emmanuel& Karikari, Thomas K.. 2015. Motor Neuron Diseases in Sub-Saharan Africa: The Need for More Population-Based Studies. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054954
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Quansah, Emmanuel& Karikari, Thomas K.. Motor Neuron Diseases in Sub-Saharan Africa: The Need for More Population-Based Studies. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054954
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Quansah, Emmanuel& Karikari, Thomas K.. Motor Neuron Diseases in Sub-Saharan Africa: The Need for More Population-Based Studies. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054954
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054954
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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