Improving Osteogenesis Activity on BMP-2-Immobilized PCL Fibers Modified by the γ-Ray Irradiation Technique
المؤلفون المشاركون
Lee, Jae Yong
Jeong, Won Jae
Kim, Hak-Jun
Yun, Young-Pil
Song, Jae-Jun
Park, Kyeongsoon
Song, Hae-Ryong
Kim, Sung Eun
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-18
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The purpose of this study was to demonstrate the ability of BMP-2-immobilized polycaprolactone (PCL) fibers modified using the γ-ray irradiation technique to induce the osteogenic differentiation of MG-63 cells.
Poly acrylic acid (AAc) was grafted onto the PCL fibers by the γ-ray irradiation technique.
BMP-2 was then subsequently immobilized onto the AAc-PCL fibers (BMP-2/AAc-PCL).
PCL and surface-modified PCL fibers was characterized by evaluation with a scanning electron microscope (SEM), X-ray photoelectron spectroscopy (XPS), and contact angle.
The biological activity of the PCL and surface-modified PCL fibers were characterized by alkaline phosphatase (ALP) activity, calcium deposition, and the mRNA expression of osteocalcin and osteopontin in MG-63 cells.
Successfully grafted AAc and PCL fibers with immobilized BMP-2 were confirmed by XPS results.
The results of the contact angle showed that BMP-2/AAc-PCL fibers have more hydrophilic properties in comparison to PCL fibers.
The ALP activity, calcium deposition, and gene expressions of MG-63 cells grown on BMP-2/AAc-PCL fibers showed greatly induced osteogenic differentiation in comparison to the PCL fibers.
In conclusion, these results demonstrated that BMP-2/AAc-PCL fibers have the potential to effectively induce the osteogenic differentiation of MG-63 cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yun, Young-Pil& Lee, Jae Yong& Jeong, Won Jae& Park, Kyeongsoon& Kim, Hak-Jun& Song, Jae-Jun…[et al.]. 2015. Improving Osteogenesis Activity on BMP-2-Immobilized PCL Fibers Modified by the γ-Ray Irradiation Technique. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054966
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yun, Young-Pil…[et al.]. Improving Osteogenesis Activity on BMP-2-Immobilized PCL Fibers Modified by the γ-Ray Irradiation Technique. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1054966
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yun, Young-Pil& Lee, Jae Yong& Jeong, Won Jae& Park, Kyeongsoon& Kim, Hak-Jun& Song, Jae-Jun…[et al.]. Improving Osteogenesis Activity on BMP-2-Immobilized PCL Fibers Modified by the γ-Ray Irradiation Technique. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054966
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054966
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر