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miR-34a and miR-125b Expression in HPV Infection and Cervical Cancer Development
المؤلفون المشاركون
Sousa, Hugo
Marinho-Dias, Joana
Monteiro, Paula
Loureiro, Joana
Baldaque, Inês
Medeiros, Rui
Ribeiro, Joana
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-09
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
We aimed to characterize miR-125b and miR-34a expression in 114 women with different cervical lesions: normal epithelium with (n = 20) and without (n = 29) HPV infection; LSIL (n = 28); HSIL (n = 29); and ICC (n = 8).
miRNA expression analysis was performed by comparing the distinct groups with the reference group (women with normal epithelium without HPV).
For miR-125b, we observed a twofold (2-ΔΔCt = 2.11; P = 0.038) increased expression among women with normal epithelium with HPV infection and a trend of downregulation in different cervical lesions including an 80% reduction (2-ΔΔCt = 0.21; P = 0.004) in ICC.
Similarly, miR-34a expression analysis revealed an increased expression (2-ΔΔCt = 1.69; P = 0.049) among women with normal cervix and HPV infection, and despite no significant correlation with cervical lesions, its expression was increased by twofold (2-ΔΔCt = 2.08; P = 0.042) in ICC.
Moreover, miR-125b levels were able to predict invasive cancers with 88% sensitivity and 69% specificity.
Results showed that while miR-34a expression seems to be correlated with invasive cervical cancer, miR-125b expression is significantly changed within the different cervical lesions and their levels should be further investigated as possible predictive/prognostic biomarkers using a noninvasive approach.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ribeiro, Joana& Marinho-Dias, Joana& Monteiro, Paula& Loureiro, Joana& Baldaque, Inês& Medeiros, Rui…[et al.]. 2015. miR-34a and miR-125b Expression in HPV Infection and Cervical Cancer Development. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054975
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ribeiro, Joana…[et al.]. miR-34a and miR-125b Expression in HPV Infection and Cervical Cancer Development. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1054975
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ribeiro, Joana& Marinho-Dias, Joana& Monteiro, Paula& Loureiro, Joana& Baldaque, Inês& Medeiros, Rui…[et al.]. miR-34a and miR-125b Expression in HPV Infection and Cervical Cancer Development. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054975
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054975
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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