Pretreatment Diffusion-Weighted MRI Can Predict the Response to Neoadjuvant Chemotherapy in Patients with Nasopharyngeal Carcinoma
المؤلفون المشاركون
Zhang, Guo-Yi
Wang, Yue-Jian
Liu, Jian-Ping
Zhou, Xin-Han
Xu, Zhi-Feng
Chen, Xiang-Ping
Xu, Tao
Wei, Wei-Hong
Zhang, Yang
Huang, Ying
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-27
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Purpose.
To explore the potential of diffusion-weighted (DW) magnetic resonance imaging (MRI) using apparent diffusion coefficient (ADC) for predicting the response to neoadjuvant chemotherapy in nasopharyngeal carcinoma (NPC).
Methods and Materials.
Ninety-two consecutive patients with NPC who underwent three cycles of neoadjuvant chemotherapy were retrospectively analyzed.
DW and anatomical MRI were performed before and after neoadjuvant chemotherapy prior to radiotherapy.
Pretreatment ADCs and percentage increases in ADC after chemotherapy were calculated for the primary lesions and metastatic adenopathies.
Receiver operating characteristic curve analysis was used to select optimal pretreatment ADCs.
Results.
Pretreatment mean ADCs were significantly lower for responders than for nonresponders (primary lesions, P = 0.012 ; metastatic adenopathies, P = 0.013 ).
Mean percentage increases in ADC were higher for responders than for nonresponders (primary lesions, P = 0.008 ; metastatic adenopathies, P < 0.001 ).
The optimal pretreatment primary lesion and metastatic adenopathy ADCs for differentiating responders from nonresponders were 0.897 × 10−3 mm2/sec and 1.031 × 10−3 mm2/sec, respectively.
Conclusions.
NPC patients with low pretreatment ADCs tend to respond better to neoadjuvant chemotherapy.
Pretreatment ADCs could be used as a new pretreatment imaging biomarker of response to neoadjuvant chemotherapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Guo-Yi& Wang, Yue-Jian& Liu, Jian-Ping& Zhou, Xin-Han& Xu, Zhi-Feng& Chen, Xiang-Ping…[et al.]. 2015. Pretreatment Diffusion-Weighted MRI Can Predict the Response to Neoadjuvant Chemotherapy in Patients with Nasopharyngeal Carcinoma. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054988
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Guo-Yi…[et al.]. Pretreatment Diffusion-Weighted MRI Can Predict the Response to Neoadjuvant Chemotherapy in Patients with Nasopharyngeal Carcinoma. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1054988
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Guo-Yi& Wang, Yue-Jian& Liu, Jian-Ping& Zhou, Xin-Han& Xu, Zhi-Feng& Chen, Xiang-Ping…[et al.]. Pretreatment Diffusion-Weighted MRI Can Predict the Response to Neoadjuvant Chemotherapy in Patients with Nasopharyngeal Carcinoma. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054988
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054988
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر