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Synergistic Effects of BMP9 and miR-548d-5p on Promoting Osteogenic Differentiation of Mesenchymal Stem Cells
المؤلفون المشاركون
Zhou, Yan
Zhang, Licheng
Zhang, Wei
Ji, XinRan
Liu, JianHeng
Liu, DaoHong
Yin, Peng
Peng, Ye
Hao, Ming
Zhang, LiHai
Tang, PeiFu
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-01
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Various stimulators have been reported to promote MSC osteogenic differentiation via different pathways such as bone morphogenetic protein 9 (BMP9) through influencing COX-2 and miR-548d-5p through targeting peroxisome proliferator-activated receptor-γ (PPARγ).
Whether synergistic effects between BMP9 and miR-548d-5p existed in promoting osteogenesis from MSCs was unclear.
In the study, the potential synergistic effects of BMP9 and miR-548d-5p on human MSC differentiation were investigated.
Osteogenic differentiation of MSCs treated with BMP9 or miR-548d-5p was detected with multimodality of methods.
The results demonstrated that BMP9 and miR-548d-5p significantly influenced COX-2 and PPARγ, respectively.
BMP9 also influenced the expression of PPARγ, but no significant effect of miR-548d-5p on COX-2 was observed.
When BMP9 and miR-548d-5p were combined, more potent effects on both COX-2 and PPARγ were observed than BMP9 or miR-548d-5p alone.
Consistently, osteogenic analysis at different timepoints demonstrated that osteogenic genes, ALP activity, calcium deposition, OPN protein, and matrix mineralization were remarkably upregulated by BMP9/miR-548d-5p compared with BMP9 or miR-548d-5p alone, indicating the synergetic effects of BMP9 and miR-548d-5p on osteogenic differentiation of MSCs.
Our study demonstrated that regulating different osteogenic regulators may be an effective strategy to promote bone tissue regeneration for bone defects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Wei& Zhang, Licheng& Zhou, Yan& Ji, XinRan& Liu, JianHeng& Liu, DaoHong…[et al.]. 2015. Synergistic Effects of BMP9 and miR-548d-5p on Promoting Osteogenic Differentiation of Mesenchymal Stem Cells. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054998
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Wei…[et al.]. Synergistic Effects of BMP9 and miR-548d-5p on Promoting Osteogenic Differentiation of Mesenchymal Stem Cells. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054998
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Wei& Zhang, Licheng& Zhou, Yan& Ji, XinRan& Liu, JianHeng& Liu, DaoHong…[et al.]. Synergistic Effects of BMP9 and miR-548d-5p on Promoting Osteogenic Differentiation of Mesenchymal Stem Cells. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054998
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1054998
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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