Large Artery Remodeling and Dynamics following Simulated Microgravity by Prolonged Head-Down Tilt Bed Rest in Humans

المؤلفون المشاركون

Palombo, Carlo
Morizzo, Carmela
Baluci, Martino
Lucini, Daniela
Ricci, Stefano
Biolo, Gianni
Tortoli, Piero
Kozakova, Michaela

المصدر

BioMed Research International

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-01-13

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الطب البشري

الملخص EN

The effects of simulated microgravity on the static and dynamic properties of large arteries are still mostly unknown.

The present study evaluated, using an integrated vascular approach, changes in structure and function of the common carotid and femoral arteries (CCA and CFA) after prolonged head-down tilt bed rest (HDTBR).

Ten healthy men were enrolled in a 5-week HDTBR study endorsed by the Italian Space Agency (ASI).

Arterial geometry, flow, stiffness, and shear rate were evaluated by ultrasound.

Local carotid pulse pressure and wave reflection were studied by applanation tonometry.

After five weeks of HDTBR, CFA showed a decrease in lumen diameter without significant changes in wall thickness (IMT), resulting in an inward remodeling.

Local carotid pulse pressure decreased and carotid-to-brachial pressure amplification increased.

The ratio of systolic-to-diastolic volumetric flow in CFA decreased, whereas in CCA it tended to increase.

Indices of arterial stiffness and shear rate did not change during HDTBR, either in CCA or CFA.

In summary, prolonged HDTBR has a different impact on CCA and CFA structure and flow, probably depending on the characteristics of the vascular bed perfused.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Palombo, Carlo& Morizzo, Carmela& Baluci, Martino& Lucini, Daniela& Ricci, Stefano& Biolo, Gianni…[et al.]. 2015. Large Artery Remodeling and Dynamics following Simulated Microgravity by Prolonged Head-Down Tilt Bed Rest in Humans. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055116

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Palombo, Carlo…[et al.]. Large Artery Remodeling and Dynamics following Simulated Microgravity by Prolonged Head-Down Tilt Bed Rest in Humans. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1055116

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Palombo, Carlo& Morizzo, Carmela& Baluci, Martino& Lucini, Daniela& Ricci, Stefano& Biolo, Gianni…[et al.]. Large Artery Remodeling and Dynamics following Simulated Microgravity by Prolonged Head-Down Tilt Bed Rest in Humans. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055116

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1055116