Third-Degree Hindpaw Burn Injury Induced Apoptosis of Lumbar Spinal Cord Ventral Horn Motor Neurons and Sciatic Nerve and Muscle Atrophy in Rats

المؤلفون المشاركون

Kwan, Aij-Lie
Hsu, Yi-Chiang
Huang, Shu-Hung
Wu, Sheng-Hua
Chai, Chee-Yin
Yeh, Jwu-Lai
Wu, Tai-Cheng
Cheng, Kuang I.

المصدر

BioMed Research International

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-01-28

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الطب البشري

الملخص EN

Background.

Severe burns result in hypercatabolic state and concomitant muscle atrophy that persists for several months, thereby limiting patient recovery.

However, the effects of burns on the corresponding spinal dermatome remain unknown.

This study aimed to investigate whether burns induce apoptosis of spinal cord ventral horn motor neurons (VHMNs) and consequently cause skeletal muscle wasting.

Methods.

Third-degree hindpaw burn injury with 1% total body surface area (TBSA) rats were euthanized 4 and 8 weeks after burn injury.

The apoptosis profiles in the ventral horns of the lumbar spinal cords, sciatic nerves, and gastrocnemius muscles were examined.

The Schwann cells in the sciatic nerve were marked with S100.

The gastrocnemius muscles were harvested to measure the denervation atrophy.

Result.

The VHMNs apoptosis in the spinal cord was observed after inducing third-degree burns in the hindpaw.

The S100 and TUNEL double-positive cells in the sciatic nerve increased significantly after the burn injury.

Gastrocnemius muscle apoptosis and denervation atrophy area increased significantly after the burn injury.

Conclusion.

Local hindpaw burn induces apoptosis in VHMNs and Schwann cells in sciatic nerve, which causes corresponding gastrocnemius muscle denervation atrophy.

Our results provided an animal model to evaluate burn-induced muscle wasting, and elucidate the underlying mechanisms.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Wu, Sheng-Hua& Huang, Shu-Hung& Cheng, Kuang I.& Chai, Chee-Yin& Yeh, Jwu-Lai& Wu, Tai-Cheng…[et al.]. 2015. Third-Degree Hindpaw Burn Injury Induced Apoptosis of Lumbar Spinal Cord Ventral Horn Motor Neurons and Sciatic Nerve and Muscle Atrophy in Rats. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055229

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Wu, Sheng-Hua…[et al.]. Third-Degree Hindpaw Burn Injury Induced Apoptosis of Lumbar Spinal Cord Ventral Horn Motor Neurons and Sciatic Nerve and Muscle Atrophy in Rats. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1055229

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Wu, Sheng-Hua& Huang, Shu-Hung& Cheng, Kuang I.& Chai, Chee-Yin& Yeh, Jwu-Lai& Wu, Tai-Cheng…[et al.]. Third-Degree Hindpaw Burn Injury Induced Apoptosis of Lumbar Spinal Cord Ventral Horn Motor Neurons and Sciatic Nerve and Muscle Atrophy in Rats. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055229

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1055229