Transcriptional Pathways Associated with Skeletal Muscle Changes after Spinal Cord Injury and Treadmill Locomotor Training
المؤلفون المشاركون
Pandey, Sachidanand
Baligand, Celine
Chen, Yi-Wen
Ye, Fan
Lai, San-Huei
Liu, Min
Vandenborne, Krista
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-24
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The genetic and molecular events associated with changes in muscle mass andfunction after SCI and after the implementation of candidate therapeuticapproaches are still not completely known.
The overall objective of this study wasto identify key molecular pathways activated with muscle remodeling after SCIand locomotor training.
We implemented treadmill training in a well-characterizedrat model of moderate SCI and performed genome wide expression profiling onsoleus muscles at multiple time points: 3, 8, and 14 days after SCI.
We found that theactivity of the protein ubiquitination and mitochondrial function related pathwayswas altered with SCI and corrected with treadmill training.
The BMP pathway wasdifferentially activated with early treadmill training as shown by IngenuityPathway Analysis.
The expression of several muscle mass regulators wasmodulated by treadmill training, including Fst, Jun, Bmpr2, Actr2b, and Smad3.
Inaddition, key players in fatty acids metabolism (Lpl and Fabp3) responded toboth SCI induced inactivity and reloading with training.
The decrease in Smad3 and Fst early after the initiation of treadmill training was confirmed by RT-PCR.
Our data suggest that TGFβ/Smad3 signaling may be mainly involved in the decrease in muscle mass observed with SCI, while the BMP pathway was activated with treadmill training.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Baligand, Celine& Chen, Yi-Wen& Ye, Fan& Pandey, Sachidanand& Lai, San-Huei& Liu, Min…[et al.]. 2015. Transcriptional Pathways Associated with Skeletal Muscle Changes after Spinal Cord Injury and Treadmill Locomotor Training. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055281
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Baligand, Celine…[et al.]. Transcriptional Pathways Associated with Skeletal Muscle Changes after Spinal Cord Injury and Treadmill Locomotor Training. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1055281
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Baligand, Celine& Chen, Yi-Wen& Ye, Fan& Pandey, Sachidanand& Lai, San-Huei& Liu, Min…[et al.]. Transcriptional Pathways Associated with Skeletal Muscle Changes after Spinal Cord Injury and Treadmill Locomotor Training. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055281
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055281
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر