Neuroprotective Effect of Sodium Butyrate against Cerebral IschemiaReperfusion Injury in Mice
المؤلفون المشاركون
Sun, Jing
Wang, Fangyan
Li, Haixiao
Zhang, Huiqing
Jin, Jiangtao
Chen, Wenqian
Pang, Mengqi
Yu, Junjie
He, Yiwen
Liu, Jiaming
Liu, Chunfeng
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-07
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Sodium butyrate (NaB) is a dietary microbial fermentation product of fiber and serves as an important neuromodulator in the central nervous system.
In this study, we further investigated that NaB attenuated cerebral ischemia/reperfusion (I/R) injury in vivo and its possible mechanisms.
NaB (5, 10 mg/kg) was administered intragastrically 3 h after the onset of reperfusion in bilateral common carotid artery occlusion (BCCAO) mice.
After 24 h of reperfusion, neurological deficits scores were estimated.
Morphological examination was performed by electron microscopy and hematoxylin-eosin (H&E) staining.
The levels of oxidative stress and inflammatory cytokines were assessed.
Apoptotic neurons were measured by TUNEL; apoptosis-related protein caspase-3, Bcl-2, Bax, the phosphorylation Akt (p-Akt), and BDNF were assayed by western blot and immunohistochemistry.
The results showed that 10 mg/kg NaB treatment significantly ameliorated neurological deficit and histopathology changes in cerebral I/R injury.
Moreover, 10 mg/kg NaB treatment markedly restored the levels of MDA, SOD, IL-1β, TNF-α, and IL-8.
10 mg/kg NaB treatment also remarkably inhibited the apoptosis, decreasing the levels of caspase-3 and Bax and increasing the levels of Bcl-2, p-Akt, and BDNF.
This study suggested that NaB exerts neuroprotective effects on cerebral I/R injury by antioxidant, anti-inflammatory, and antiapoptotic properties and BDNF-PI3K/Akt pathway is involved in antiapoptotic effect.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sun, Jing& Wang, Fangyan& Li, Haixiao& Zhang, Huiqing& Jin, Jiangtao& Chen, Wenqian…[et al.]. 2015. Neuroprotective Effect of Sodium Butyrate against Cerebral IschemiaReperfusion Injury in Mice. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055319
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sun, Jing…[et al.]. Neuroprotective Effect of Sodium Butyrate against Cerebral IschemiaReperfusion Injury in Mice. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1055319
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sun, Jing& Wang, Fangyan& Li, Haixiao& Zhang, Huiqing& Jin, Jiangtao& Chen, Wenqian…[et al.]. Neuroprotective Effect of Sodium Butyrate against Cerebral IschemiaReperfusion Injury in Mice. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055319
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055319
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر