A miRNA-Driven Inference Model to Construct Potential Drug-Disease Associations for Drug Repositioning
المؤلفون المشاركون
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-19
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Increasing evidence discovered that the inappropriate expression of microRNAs (miRNAs) will lead to many kinds of complex diseases and drugs can regulate the expression level of miRNAs.
Therefore human diseases may be treated by targeting some specific miRNAs with drugs, which provides a new perspective for drug repositioning.
However, few studies have attempted to computationally predict associations between drugs and diseases via miRNAs for drug repositioning.
In this paper, we developed an inference model to achieve this aim by combining experimentally supported drug-miRNA associations and miRNA-disease associations with the assumption that drugs will form associations with diseases when they share some significant miRNA partners.
Experimental results showed excellent performance of our model.
Case studies demonstrated that some of the strongly predicted drug-disease associations can be confirmed by the publicly accessible database CTD (www.ctdbase.org), which indicated the usefulness of our inference model.
Moreover, candidate miRNAs as molecular hypotheses underpinning the associations were listed to guide future experiments.
The predicted results were released for further studies.
We expect that this study will provide help in our understanding of drug-disease association prediction and in the roles of miRNAs in drug repositioning.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Hailin& Zhang, Zuping. 2015. A miRNA-Driven Inference Model to Construct Potential Drug-Disease Associations for Drug Repositioning. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055364
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Hailin& Zhang, Zuping. A miRNA-Driven Inference Model to Construct Potential Drug-Disease Associations for Drug Repositioning. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1055364
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Hailin& Zhang, Zuping. A miRNA-Driven Inference Model to Construct Potential Drug-Disease Associations for Drug Repositioning. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055364
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055364
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر