LINE-1 Methylation Patterns as a Predictor of Postmolar Gestational Trophoblastic Neoplasia
المؤلفون المشاركون
Lertkhachonsuk, Ruangsak
Paiwattananupant, Krissada
Tantbirojn, Patou
Rattanatanyong, Prakasit
Mutirangura, Apiwat
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-13
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
To study the potential of long interspersed element-1 (LINE-1) methylation change in the prediction of postmolar gestational trophoblastic neoplasia (GTN).
Methods.
The LINE-1 methylation pattern from first trimester placenta, hydatidiform mole, and malignant trophoblast specimens were compared.
Then, hydatidiform mole patients from 11999 to 2010 were classified into the following 2 groups: a remission group and a group that developed postmolar GTN.
Specimens were prepared for a methylation study.
The methylation levels and percentages of LINE-1 loci were evaluated for their sensitivity, specificity, and accuracy for the prediction of postmolar GTN.
Results.
First, 12 placentas, 38 moles, and 19 malignant trophoblast specimens were compared.
The hydatidiform mole group had the highest LINE-1 methylation level ( p = 0.003) and the uCuC of LINE-1 increased in the malignant trophoblast group ( p ≤ 0.001).
One hundred forty-five hydatidiform mole patients were classified as 103 remission and 42 postmolar GTN patients.
The %mCuC and %uCmC of LINE-1 showed the lowest p value for distinguishing between the two groups ( p < 0.001).
The combination of the pretreatment β-hCG level (≥100,000 mIU/mL) with the %mCuC and %uCmC, sensitivity, specificity, PPV, NPV, and accuracy modified the levels to 60.0%, 92.2%, 77.4%, 83.8%, and 82.3%, respectively.
Conclusions.
A reduction in the partial methylation of LINE-1 occurs early before the clinical appearance of malignant transformation.
The %mCuC and %uCmC of LINE-1s may be promising markers for monitoring hydatidiform moles before progression to GTN.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lertkhachonsuk, Ruangsak& Paiwattananupant, Krissada& Tantbirojn, Patou& Rattanatanyong, Prakasit& Mutirangura, Apiwat. 2015. LINE-1 Methylation Patterns as a Predictor of Postmolar Gestational Trophoblastic Neoplasia. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055433
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lertkhachonsuk, Ruangsak…[et al.]. LINE-1 Methylation Patterns as a Predictor of Postmolar Gestational Trophoblastic Neoplasia. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1055433
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lertkhachonsuk, Ruangsak& Paiwattananupant, Krissada& Tantbirojn, Patou& Rattanatanyong, Prakasit& Mutirangura, Apiwat. LINE-1 Methylation Patterns as a Predictor of Postmolar Gestational Trophoblastic Neoplasia. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055433
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055433
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر