Mechanical Stress Promotes Cisplatin-Induced Hepatocellular Carcinoma Cell Death
المؤلفون المشاركون
Ziko, Laila
Riad, Sandra
Amer, Momen
Amleh, Asma
Zdero, Radovan
Bougherara, Habiba
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-22
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Cisplatin (CisPt) is a commonly used platinum-based chemotherapeutic agent.
Its efficacy is limited due to drug resistance and multiple side effects, thereby warranting a new approach to improving the pharmacological effect of CisPt.
A newly developed mathematical hypothesis suggested that mechanical loading, when coupled with a chemotherapeutic drug such as CisPt and immune cells, would boost tumor cell death.
The current study investigated the aforementioned mathematical hypothesis by exposing human hepatocellular liver carcinoma (HepG2) cells to CisPt, peripheral blood mononuclear cells, and mechanical stress individually and in combination.
HepG2 cells were also treated with a mixture of CisPt and carnosine with and without mechanical stress to examine one possible mechanism employed by mechanical stress to enhance CisPt effects.
Carnosine is a dipeptide that reportedly sequesters platinum-based drugs away from their pharmacological target-site.
Mechanical stress was achieved using an orbital shaker that produced 300 rpm with a horizontal circular motion.
Our results demonstrated that mechanical stress promoted CisPt-induced death of HepG2 cells (~35% more cell death).
Moreover, results showed that CisPt-induced death was compromised when CisPt was left to mix with carnosine 24 hours preceding treatment.
Mechanical stress, however, ameliorated cell death (20% more cell death).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ziko, Laila& Riad, Sandra& Amer, Momen& Zdero, Radovan& Bougherara, Habiba& Amleh, Asma. 2015. Mechanical Stress Promotes Cisplatin-Induced Hepatocellular Carcinoma Cell Death. BioMed Research International،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1055462
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ziko, Laila…[et al.]. Mechanical Stress Promotes Cisplatin-Induced Hepatocellular Carcinoma Cell Death. BioMed Research International No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1055462
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ziko, Laila& Riad, Sandra& Amer, Momen& Zdero, Radovan& Bougherara, Habiba& Amleh, Asma. Mechanical Stress Promotes Cisplatin-Induced Hepatocellular Carcinoma Cell Death. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1055462
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055462
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر