LAP TGF-Beta Subset of CD4+CD25+CD127− Treg Cells is Increased and Overexpresses LAP TGF-Beta in Lung Adenocarcinoma Patients
المؤلفون المشاركون
Romero-Garcia, Susana
Prado-Garcia, Heriberto
Islas-Vazquez, Lorenzo
Galicia-Velasco, Miriam
Camacho-Mendoza, Catalina
Aguilar-Cazares, Dolores
Lopez-Gonzalez, Jose Sullivan
Meneses-Flores, Manuel
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-25
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Lung cancer is the leading cause of cancer death worldwide.
Adenocarcinoma, the most commonly diagnosed histologic type of lung cancer, is associated with smoking.
Cigarette smoke promotes inflammation on the airways, which might be mediated by Th17 cells.
This inflammatory environment may contribute to tumor development.
In contrast, some reports indicate that tumors may induce immunosuppressive Treg cells to dampen immune reactivity, supporting tumor growth and progression.
Thus, we aimed to analyze whether chronic inflammation or immunosuppression predominates at the systemic level in lung adenocarcinoma patients, and several cytokines and Th17 and Treg cells were studied.
Higher proportions of IL-17-producing CD4+ T-cells were found in smoking control subjects and in lung adenocarcinoma patients compared to nonsmoking control subjects.
In addition, lung adenocarcinoma patients increased both plasma concentrations of IL-2, IL-4, IL-6, and IL-10, and proportions of Latency Associated Peptide (LAP) TGF-β subset of CD4+CD25+CD127− Treg cells, which overexpressed LAP TGF-β.
This knowledge may lead to the development of immunotherapies that could inhibit the suppressor activity mediated by the LAP TGF-β subset of CD4+CD25+CD127− Treg cells to promote reactivity of immune cells against lung adenocarcinoma cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Islas-Vazquez, Lorenzo& Prado-Garcia, Heriberto& Aguilar-Cazares, Dolores& Meneses-Flores, Manuel& Galicia-Velasco, Miriam& Romero-Garcia, Susana…[et al.]. 2015. LAP TGF-Beta Subset of CD4+CD25+CD127− Treg Cells is Increased and Overexpresses LAP TGF-Beta in Lung Adenocarcinoma Patients. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055465
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Islas-Vazquez, Lorenzo…[et al.]. LAP TGF-Beta Subset of CD4+CD25+CD127− Treg Cells is Increased and Overexpresses LAP TGF-Beta in Lung Adenocarcinoma Patients. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1055465
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Islas-Vazquez, Lorenzo& Prado-Garcia, Heriberto& Aguilar-Cazares, Dolores& Meneses-Flores, Manuel& Galicia-Velasco, Miriam& Romero-Garcia, Susana…[et al.]. LAP TGF-Beta Subset of CD4+CD25+CD127− Treg Cells is Increased and Overexpresses LAP TGF-Beta in Lung Adenocarcinoma Patients. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055465
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055465
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر