Assessing the Impact of Mechanical Damage on Full-Thickness Porcine and Human Skin Using an In Vitro Approach
المؤلفون المشاركون
Dabboue, Hinda
Builles, Nicolas
Frouin, Éric
Scott, Dan
Ramos, Jeanne
Marti-Mestres, Gilberte
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-13
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
For most xenobiotics, the rates of percutaneous absorption are limited by diffusion through the horny layer of skin.
However, percutaneous absorption of chemicals may seriously increase when the skin is damaged.
The aim of this work was to develop an in vitro representative model of mechanically damaged skins.
The epidermal barrier was examined following exposure to a razor, a rotating brush, and a microneedle system in comparison to tape-stripping which acted as a reference.
Excised full-thickness skins were mounted on a diffusion chamber in order to evaluate the effect of injuries and to mimic physiological conditions.
The transepidermal water loss (TEWL) was greatly increased when the barrier function was compromised.
Measurements were made for all the damaged biopsies and observed histologically by microscopy.
On human and porcine skins, the tape-stripping application (0 to 40 times) showed a proportional increase in TEWL which highlights the destruction of the stratum corneum.
Similar results were obtained for all cosmetic instruments.
This is reflected in our study by the nonsignificant difference of the mean TEWL scores between 30 strips and mechanical damage.
For a specific appreciation, damaged skins were then selected to qualitatively evaluate the absorption of a chlorogenic acid solution using fluorescence microscopy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dabboue, Hinda& Builles, Nicolas& Frouin, Éric& Scott, Dan& Ramos, Jeanne& Marti-Mestres, Gilberte. 2015. Assessing the Impact of Mechanical Damage on Full-Thickness Porcine and Human Skin Using an In Vitro Approach. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055475
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dabboue, Hinda…[et al.]. Assessing the Impact of Mechanical Damage on Full-Thickness Porcine and Human Skin Using an In Vitro Approach. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1055475
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dabboue, Hinda& Builles, Nicolas& Frouin, Éric& Scott, Dan& Ramos, Jeanne& Marti-Mestres, Gilberte. Assessing the Impact of Mechanical Damage on Full-Thickness Porcine and Human Skin Using an In Vitro Approach. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055475
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055475
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر