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Multiple Sclerosis in Older Adults: The Clinical Profile and Impact of Interferon Beta Treatment
المؤلفون المشاركون
Shirani, Afsaneh
Zhao, Yinshan
Petkau, John
Gustafson, Paul
Karim, Mohammad Ehsanul
Evans, Charity
Kingwell, Elaine
van der Kop, Mia L.
Oger, Joel
Tremlett, Helen
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-01
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
We examined (1) patient characteristics and disease-modifying drug (DMD) exposure in late-onset (LOMS, ≥50 years at symptom onset) versus adult-onset (AOMS, 18–<50 years) MS and (2) the association between interferon-beta (IFNβ) and disability progression in older relapsing-onset MS adults (≥50 years).
Methods.
This retrospective study (1980–2004, British Columbia, Canada) included 358 LOMS and 5627 AOMS patients.
IFNβ-treated relapsing-onset MS patients aged ≥50 (regardless of onset age, 90) were compared with 171 contemporary and 106 historical controls.
Times to EDSS 6 from onset and from IFNβ eligibility were examined using survival analyses.
Results.
LOMS patients (6%) were more likely to be male, with motor onset and a primary-progressive course, and exhibit faster progression and were less likely to take DMDs.
Nonetheless, 57% were relapsing-onset, of which 31% were prescribed DMDs, most commonly IFNβ.
Among older relapsing-onset MS adults, no significant association between IFNβ exposure and disability progression was found when either the contemporary (hazard ratio [HR]: 0.46; 95% CI: 0.18–1.22) or historical controls (HR: 0.54; 95% CI: 0.20–1.42) were considered.
Conclusion.
LOMS differed clinically from AOMS.
One-third of older relapsing-onset MS patients were prescribed a DMD.
IFNβ exposure was not significantly associated with reduced disability in older MS patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shirani, Afsaneh& Zhao, Yinshan& Petkau, John& Gustafson, Paul& Karim, Mohammad Ehsanul& Evans, Charity…[et al.]. 2015. Multiple Sclerosis in Older Adults: The Clinical Profile and Impact of Interferon Beta Treatment. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055511
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shirani, Afsaneh…[et al.]. Multiple Sclerosis in Older Adults: The Clinical Profile and Impact of Interferon Beta Treatment. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1055511
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shirani, Afsaneh& Zhao, Yinshan& Petkau, John& Gustafson, Paul& Karim, Mohammad Ehsanul& Evans, Charity…[et al.]. Multiple Sclerosis in Older Adults: The Clinical Profile and Impact of Interferon Beta Treatment. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055511
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055511
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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