The Effect of Iloprost and N-Acetylcysteine on Skeletal Muscle Injury in an Acute Aortic Ischemia-Reperfusion Model: An Experimental Study
المؤلفون المشاركون
Erkoc, Kamuran
Tunerir, Bulent
Uysal, Onur
Altin, H. Firat
Gunes, Tevfik
Aydin, Selim
Tiryakioglu, Osman
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-05
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
The objective of this study was to examine the effects of iloprost and N-acetylcysteine (NAC) on ischemia-reperfusion (IR) injuries to the gastrocnemius muscle, following the occlusion-reperfusion period in the abdominal aorta of rats.
Materials and Methods.
Forty male Sprague-Dawley rats were randomly divided into four equal groups.
Group 1: control group.
Group 2 (IR): aorta was occluded.
The clamp was removed after 1 hour of ischemia.
Blood samples and muscle tissue specimens were collected following a 2-hour reperfusion period.
Group 3 (IR + iloprost): during a 1-hour ischemia period, iloprost infusion was initiated from the jugular catheter.
During a 2-hour reperfusion period, the iloprost infusion continued.
Group 4 (IR + NAC): similar to the iloprost group.
Findings.
The mean total oxidant status, CK, and LDH levels were highest in Group 2 and lowest in Group 1.
The levels of these parameters in Group 3 and Group 4 were lower compared to Group 2 and higher compared to Group 1 ( P < 0.05 ).
The histopathological examination showed that Group 3 and Group 4, compared to Group 2, had preserved appearance with respect to hemorrhage, necrosis, loss of nuclei, infiltration, and similar parameters.
Conclusion.
Iloprost and NAC are effective against ischemia-reperfusion injury and decrease ischemia-related tissue injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tiryakioglu, Osman& Erkoc, Kamuran& Tunerir, Bulent& Uysal, Onur& Altin, H. Firat& Gunes, Tevfik…[et al.]. 2015. The Effect of Iloprost and N-Acetylcysteine on Skeletal Muscle Injury in an Acute Aortic Ischemia-Reperfusion Model: An Experimental Study. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055520
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tiryakioglu, Osman…[et al.]. The Effect of Iloprost and N-Acetylcysteine on Skeletal Muscle Injury in an Acute Aortic Ischemia-Reperfusion Model: An Experimental Study. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1055520
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tiryakioglu, Osman& Erkoc, Kamuran& Tunerir, Bulent& Uysal, Onur& Altin, H. Firat& Gunes, Tevfik…[et al.]. The Effect of Iloprost and N-Acetylcysteine on Skeletal Muscle Injury in an Acute Aortic Ischemia-Reperfusion Model: An Experimental Study. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055520
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055520
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر