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Modifications in Bone Matrix of Estrogen-Deficient Rats Treated with Intermittent PTH
المؤلفون المشاركون
Pacheco-Costa, Rafael
Campos, Jenifer Freitas
Katchburian, Eduardo
de Medeiros, Valquíria Pereira
Nonaka, Keico Okino
Plotkin, Lilian Irene
Reginato, Rejane Daniele
Nader, Helena Bonciani
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-28
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Bone matrix dictates strength, elasticity, and stiffness to the bone.
Intermittent parathyroid hormone (iPTH), a bone-forming treatment, is widely used as a therapy for osteoporosis.
We investigate whether low doses of intermittent PTH (1-34) change the profile of organic components in the bone matrix after 30 days of treatment.
Forty 6-month-old female Wistar rats underwent ovariectomy and after 3 months received low doses of iPTH administered for 30 days: daily at 0.3 µg/kg/day (PTH03) or 5 µg/kg/day (PTH5); or 3 times per week at 0.25 µg/kg/day (PTH025).
After euthanasia, distal femora were processed for bone histomorphometry, histochemistry for collagen and glycosaminoglycans, biochemical quantification of sulfated glycosaminoglycans, and hyaluronan by ELISA and TUNEL staining.
Whole tibiae were used to estimate the bone mineral density (BMD).
Histomorphometric analysis showed that PTH5 increased cancellous bone volume by 6% over vehicle-treated rats.
In addition, PTH5 and PTH03 increased cortical thickness by 21% and 20%, respectively.
Tibial BMD increased in PTH5-treated rats and this group exhibited lower levels of chondroitin sulfate; on the other hand, hyaluronan expression was increased.
Hormonal administration in the PTH5 group led to decreased collagen maturity.
Further, TUNEL-positive osteocytes were decreased in the cortical compartment of PTH5 whereas administration of PTH025 increased the osteocyte death.
Our findings suggest that daily injections of PTH at low doses alter the pattern of organic components from the bone matrix, favoring the increase of bone mass.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pacheco-Costa, Rafael& Campos, Jenifer Freitas& Katchburian, Eduardo& de Medeiros, Valquíria Pereira& Nader, Helena Bonciani& Nonaka, Keico Okino…[et al.]. 2015. Modifications in Bone Matrix of Estrogen-Deficient Rats Treated with Intermittent PTH. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055528
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pacheco-Costa, Rafael…[et al.]. Modifications in Bone Matrix of Estrogen-Deficient Rats Treated with Intermittent PTH. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1055528
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pacheco-Costa, Rafael& Campos, Jenifer Freitas& Katchburian, Eduardo& de Medeiros, Valquíria Pereira& Nader, Helena Bonciani& Nonaka, Keico Okino…[et al.]. Modifications in Bone Matrix of Estrogen-Deficient Rats Treated with Intermittent PTH. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055528
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055528
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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