miRNA Profiles of Tubular Cells: Diagnosis of Kidney Injury
المؤلفون المشاركون
Endo, Kosuke
Ikesue, Masahiro
Iwai, Naoharu
Kito, Naoko
Weng, Huachun
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
MicroRNAs (miRNAs) are small noncoding RNAs of 18–23 nucleotides that regulate gene expression.
Recently, plasma miRNAs have been investigated as biomarkers for various physiological and pathological conditions.
The present study details the conserved miRNA expression profiles of tubular tissues, and discusses whether they could be used to distinguish between proximal tubule injury, diagnose acute kidney injury (AKI), and the early-stage renal tubular dysfunction.
miRNA expression was assessed with miRNA array and real-time reverse transcription polymerase chain reaction using the TaqMan system.
The expression profiles of miR-200a/b/c, miR-145, miR-192, miR-194, miR-216a/b, miR-217, and miR-449a in human and rat tubular tissues such as the kidneys, lung, small intestine, and various exocrine glands were adequate for discriminating tubular tissues.
In the kidney, miR-192 and miR-194 were highly expressed, whereas miR-145 and miR-449a were absent.
miR-145 and miR-449a were relatively specifically expressed in small intestine and lung, respectively.
Therefore, the combined levels of miR-200a/b/c, miR-192, and miR-194 in plasma were very useful in diagnosing AKI induced by contact freezing in mice.
Moreover, urinary miR-200a levels were useful for the diagnosis of renal tubular dysfunction in Dahl salt-sensitive rat with high salt administration.
Our results indicate that miRNA expression profiles are useful as biomarkers for identification of various kidney injuries.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kito, Naoko& Endo, Kosuke& Ikesue, Masahiro& Weng, Huachun& Iwai, Naoharu. 2015. miRNA Profiles of Tubular Cells: Diagnosis of Kidney Injury. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055584
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kito, Naoko…[et al.]. miRNA Profiles of Tubular Cells: Diagnosis of Kidney Injury. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1055584
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kito, Naoko& Endo, Kosuke& Ikesue, Masahiro& Weng, Huachun& Iwai, Naoharu. miRNA Profiles of Tubular Cells: Diagnosis of Kidney Injury. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055584
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055584
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر