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Cholesteryl Pullulan Encapsulated TNF-α Nanoparticles Are an Effective Mucosal Vaccine Adjuvant against Influenza Virus
المؤلفون المشاركون
Nagatomo, Daiki
Taniai, Madoka
Ariyasu, Harumi
Taniguchi, Mutsuko
Aga, Miho
Ariyasu, Toshio
Ohta, Tsunetaka
Fukuda, Shigeharu
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-01
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
We encapsulated tumor necrosis factor-α (TNF-α), a major proinflammatory cytokine, into cholesteryl pullulan (CHP) to prepare TNF/CHP nanoparticles.
In this report, we describe the immune-enhancing capability of the nanoparticles to act as a vaccine adjuvant.
TNF/CHP nanoparticles showed excellent storage stability and enhanced host immune responses to external immunogens.
The nanoparticles were effective via the nasal route of administration for inducing systemic IgG1 as well as mucosal IgA.
We applied the nanoparticles in a model experimental influenza virus infection to investigate their adjuvant ability.
TNF/CHP nanoparticles combined with a conventional split vaccine protected mice via nasal administration against a lethal challenge of A/PR/8/34 (H1N1) influenza virus.
Mechanistic studies showed that the nanoparticles enhanced antigen uptake by dendritic cells (DCs) and moderately induced the expression of inflammation-related genes in nasopharynx lymphoid tissue (NALT), leading to the activation of both B and T cells.
Preliminary safety study revealed no severe toxicity to TNF/CHP nanoparticles.
Slight-to-moderate influences in nasal mucosa were observed only in the repeated administration and they seemed to be reversible.
Our data show that TNF/CHP nanoparticles effectively enhance both humoral and cellular immunity and could be a potential adjuvant for vaccines against infectious diseases, especially in the mucosa.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nagatomo, Daiki& Taniai, Madoka& Ariyasu, Harumi& Taniguchi, Mutsuko& Aga, Miho& Ariyasu, Toshio…[et al.]. 2015. Cholesteryl Pullulan Encapsulated TNF-α Nanoparticles Are an Effective Mucosal Vaccine Adjuvant against Influenza Virus. BioMed Research International،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1055605
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nagatomo, Daiki…[et al.]. Cholesteryl Pullulan Encapsulated TNF-α Nanoparticles Are an Effective Mucosal Vaccine Adjuvant against Influenza Virus. BioMed Research International No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1055605
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nagatomo, Daiki& Taniai, Madoka& Ariyasu, Harumi& Taniguchi, Mutsuko& Aga, Miho& Ariyasu, Toshio…[et al.]. Cholesteryl Pullulan Encapsulated TNF-α Nanoparticles Are an Effective Mucosal Vaccine Adjuvant against Influenza Virus. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1055605
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055605
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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