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Potential Utility of Novel Biomarkers in Active Surveillance of Low-Risk Prostate Cancer
المؤلفون المشاركون
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-03
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Active surveillance (AS) is now an accepted management strategy for men with low-risk localized prostate cancer (PCa).
However, detecting disease progression in a patient selected for AS remains a challenge.
It is crucial to know what will serve as the best parameter to correctly identify tumors that progress to a more aggressive phenotype so as not to miss the window of curability.
Several biomarkers are now being actively investigated as novel tools to improve PCa risk assessments.
To date, several serum, urinary, and tissue biomarkers have shown promising prognostic value.
%[−2]proPSA and PHI showed improved predictive value for an unfavorable biopsy conversion at annual surveillance biopsy in the AS program.
PCA3 and TMPRSS2:ERG had additional independent predictive value for the prediction of PCa detection and progression, although PCA3 was limited in predicting aggressive cancer.
Other tissue biomarkers also showed promising ability to predict disease progression.
Although several of these novel biomarkers have an improved predictive accuracy that is better than classical parameters, there is still a need for further well-designed, large, multicenter, prospective trials to avoid common bias and clinical validation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Jeong Hyun& Hong, Sung Kyu. 2015. Potential Utility of Novel Biomarkers in Active Surveillance of Low-Risk Prostate Cancer. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055619
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Jeong Hyun& Hong, Sung Kyu. Potential Utility of Novel Biomarkers in Active Surveillance of Low-Risk Prostate Cancer. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1055619
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Jeong Hyun& Hong, Sung Kyu. Potential Utility of Novel Biomarkers in Active Surveillance of Low-Risk Prostate Cancer. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055619
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055619
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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