BRAF Testing in Multifocal Papillary Thyroid Carcinoma
المؤلفون المشاركون
Bhatia, Parisha
Kimbrell, Hillary Z.
Sholl, Andrew B.
Ratnayaka, Swarnamala
Japa, Shanker
Lacey, Michelle
Carpio, Gandahari
Kandil, Emad
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-13
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
BRAF V600E mutation is associated with poor prognosis in patients with papillary thyroid carcinoma (PTC).
PTC is often multifocal, and there are no guidelines on how many tumors to test for BRAF mutation in multifocal PTC.
Methods.
Fifty-seven separate formalin-fixed and paraffin-embedded PTCs from twenty-seven patients were manually macrodissected and tested for BRAF mutation using a commercial allele-specific real-time polymerase chain reaction-based assay (Entrogen, Woodland Hills, CA).
Data related to histologic characteristics, patient demographics, and clinical outcomes were collected.
Results.
All mutations detected were BRAF V600E.
Seventeen patients (63%) had concordant mutation status in the largest and second-largest tumors (i.e., both were positive or both were negative).
The remaining ten patients (37%) had discordant mutation status.
Six of the patients with discordant tumors (22% overall) had a BRAF-negative largest tumor and a BRAF-positive second-largest tumor.
No histologic feature was found to help predict which cases would be discordant.
Conclusions.
Patients with multifocal PTC whose largest tumor is BRAF-negative can have smaller tumors that are BRAF-positive.
Therefore, molecular testing of more than just the dominant tumor should be considered.
Future studies are warranted to establish whether finding a BRAF mutation in a smaller tumor has clinical significance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ratnayaka, Swarnamala& Japa, Shanker& Lacey, Michelle& Carpio, Gandahari& Bhatia, Parisha& Kandil, Emad…[et al.]. 2015. BRAF Testing in Multifocal Papillary Thyroid Carcinoma. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055664
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ratnayaka, Swarnamala…[et al.]. BRAF Testing in Multifocal Papillary Thyroid Carcinoma. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1055664
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ratnayaka, Swarnamala& Japa, Shanker& Lacey, Michelle& Carpio, Gandahari& Bhatia, Parisha& Kandil, Emad…[et al.]. BRAF Testing in Multifocal Papillary Thyroid Carcinoma. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055664
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055664
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر