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Evaluation of Single-Impact-Induced Cartilage Degeneration by Optical Coherence Tomography
المؤلفون المشاركون
Pufe, T.
de Bont, Florence
Brill, Nicolai
Schmitt, Robert
Tingart, Markus
Jahr, Holger
Nebelung, Sven
Rath, Bjoern
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-01
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Posttraumatic osteoarthritis constitutes a major cause of disability in our increasingly elderly population.
Unfortunately, current imaging modalities are too insensitive to detect early degenerative changes of this disease.
Optical coherence tomography (OCT) is a promising nondestructive imaging technique that allows surface and subsurface imaging of cartilage, at near-histological resolution, and is principally applicable in vivo during arthroscopy.
Thirty-four macroscopically normal human cartilage-bone samples obtained from total joint replacements were subjected to standardized single impacts in vitro (range: 0.25 J to 0.98 J).
3D OCT measurements of impact area and adjacent tissue were performed prior to impaction, directly after impaction, and 1, 4, and 8 days later.
OCT images were assessed qualitatively (DJD classification) and quantitatively using established parameters (OII, Optical Irregularity Index; OHI, Optical Homogeneity Index; OAI, Optical Attenuation Index) and compared to corresponding histological sections.
While OAI and OHI scores were not significantly changed in response to low- or moderate-impact energies, high-impact energies significantly increased mean DJD grades (histology and OCT) and OII scores.
In conclusion, OCT-based parameterization and quantification are able to reliably detect loss of cartilage surface integrity after high-energy traumatic insults and hold potential to be used for clinical screening of early osteoarthritis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
de Bont, Florence& Brill, Nicolai& Schmitt, Robert& Tingart, Markus& Rath, Bjoern& Pufe, T.…[et al.]. 2015. Evaluation of Single-Impact-Induced Cartilage Degeneration by Optical Coherence Tomography. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055666
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
de Bont, Florence…[et al.]. Evaluation of Single-Impact-Induced Cartilage Degeneration by Optical Coherence Tomography. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1055666
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
de Bont, Florence& Brill, Nicolai& Schmitt, Robert& Tingart, Markus& Rath, Bjoern& Pufe, T.…[et al.]. Evaluation of Single-Impact-Induced Cartilage Degeneration by Optical Coherence Tomography. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055666
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055666
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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