Vitamin D Binding Protein Is Not Involved in Vitamin D Deficiency in Patients with Chronic Kidney Disease
المؤلفون المشاركون
Kalousová, M.
Dusilova-Sulkova, Sylvie
Zakiyanov, Oskar
Kostirova, Milada
Safranek, Roman
Tesař, Vladimír
Zima, Tomáš
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-04
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
This study was designed to evaluate vitamin D status with separate determination of 25-OH D2 and 25-OH D3 and its relationship to vitamin D binding protein (VDBP) in patients with chronic kidney disease (CKD) and long-term haemodialysis patients (HD).
Methods.
45 CKD patients, 103 HD patients, and 25 controls (C) were included.
Plasma vitamin D concentrations were determined using chromatography and VDBP in serum and urine in CKD using enzyme immunoassay.
Results.
Plasma vitamin D levels were lower in CKD (30.16 ± 16.74 ng/mL) and HD (18.85 ± 15.85 ng/mL) versus C (48.72 ± 18.35 ng/mL), P<0.0001.
25-OH D3 was the dominant form of vitamin D.
Serum VDBP was higher in CKD (273.2 ± 93.8 ug/mL) versus C (222 ± 87.6 ug/mL) and HD (213.8 ± 70.9 ug/mL), P=0.0003.
Vitamin D/VDBP ratio was the highest in C and the lowest in HD; however, there was no correlation between vitamin D and VDBP.
Urinary concentration of VDBP in CKD (0.25 ± 0.13 ug/mL) correlated with proteinuria (r=0.43, P=0.003).
Conclusions.
Plasma levels of vitamin D are decreased in CKD patients and especially in HD patients.
25-OH D3 was the major form of vitamin D.
Despite urinary losses of VDBP, CKD patients had higher serum VDBP concentrations, indicating compensatory enhanced production.
Vitamin D binding protein is not involved in vitamin D deficiency.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kalousová, M.& Dusilova-Sulkova, Sylvie& Zakiyanov, Oskar& Kostirova, Milada& Safranek, Roman& Tesař, Vladimír…[et al.]. 2015. Vitamin D Binding Protein Is Not Involved in Vitamin D Deficiency in Patients with Chronic Kidney Disease. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055686
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kalousová, M.…[et al.]. Vitamin D Binding Protein Is Not Involved in Vitamin D Deficiency in Patients with Chronic Kidney Disease. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1055686
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kalousová, M.& Dusilova-Sulkova, Sylvie& Zakiyanov, Oskar& Kostirova, Milada& Safranek, Roman& Tesař, Vladimír…[et al.]. Vitamin D Binding Protein Is Not Involved in Vitamin D Deficiency in Patients with Chronic Kidney Disease. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055686
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055686
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر