Clinical Impact of the KL-6 Concentration of Pancreatic Juice for Diagnosing Pancreatic Masses

الملخص EN

Background and Aim.

Pancreatic juice cytology (PJC) is considered optimal for differentially diagnosing pancreatic masses, but the accuracy of PJC ranges from 46.7% to 93.0%.

The aim of this study was to evaluate the clinical impact of measuring the KL-6 concentration of pancreatic juice for diagnosing pancreatic masses.

Methods.

PJC and the KL-6 concentration measurements of pancreatic juice were performed for 70 consecutive patients with pancreatic masses (39 malignancies and 31 benign).

Results.

The average KL-6 concentration of pancreatic juice was significantly higher for pancreatic ductal adenocarcinomas (PDACs) (167.7±396.1 U/mL) and intraductal papillary mucinous carcinomas (IPMCs) (86.9±21.1 U/mL) than for pancreatic inflammatory lesions (17.5±15.7 U/mL, P=0.034) and intraductal papillary mucinous neoplasms (14.4±2.0 U/mL, P=0.026), respectively.

When the cut-off level of the KL-6 concentration of pancreatic juice was 16 U/mL, the sensitivity, specificity, and accuracy of the KL-6 concentration of pancreatic juice alone were 79.5%, 64.5%, and 72.9%, respectively.

Adding the KL-6 concentration of pancreatic juice to PJC when making a diagnosis caused the values of sensitivity and accuracy of PJC to increase by 15.3% (P=0.025) and 8.5% (P=0.048), respectively.

Conclusions.

The KL-6 concentration of pancreatic juice may be as useful as PJC for diagnosing PDACs.