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MatPred: Computational Identification of Mature MicroRNAs within Novel Pre-MicroRNAs
المؤلفون المشاركون
Wang, Ying
Wang, Lei
Feng, Weixing
Luan, Kuan
Dai, Xuefeng
Xu, Chengzhen
Meng, Xianglian
Zhang, Qiushi
Liang, Hong
Li, Jin
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-23
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
MicroRNAs (miRNAs) are short noncoding RNAs integral for regulating gene expression at the posttranscriptional level.
However, experimental methods often fall short in finding miRNAs expressed at low levels or in specific tissues.
While several computational methods have been developed for predicting the localization of mature miRNAs within the precursor transcript, the prediction accuracy requires significant improvement.
Methodology/Principal Findings.
Here, we present MatPred, which predicts mature miRNA candidates within novel pre-miRNA transcripts.
In addition to the relative locus of the mature miRNA within the pre-miRNA hairpin loop and minimum free energy, we innovatively integrated features that describe the nucleotide-specific RNA secondary structure characteristics.
In total, 94 features were extracted from the mature miRNA loci and flanking regions.
The model was trained based on a radial basis function kernel/support vector machine (RBF/SVM).
Our method can predict precise locations of mature miRNAs, as affirmed by experimentally verified human pre-miRNAs or pre-miRNAs candidates, thus achieving a significant advantage over existing methods.
Conclusions.
MatPred is a highly effective method for identifying mature miRNAs within novel pre-miRNA transcripts.
Our model significantly outperformed three other widely used existing methods.
Such processing prediction methods may provide important insight into miRNA biogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Jin& Wang, Ying & Wang, Lei& Feng, Weixing& Luan, Kuan& Dai, Xuefeng…[et al.]. 2015. MatPred: Computational Identification of Mature MicroRNAs within Novel Pre-MicroRNAs. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055896
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Jin…[et al.]. MatPred: Computational Identification of Mature MicroRNAs within Novel Pre-MicroRNAs. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1055896
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Jin& Wang, Ying & Wang, Lei& Feng, Weixing& Luan, Kuan& Dai, Xuefeng…[et al.]. MatPred: Computational Identification of Mature MicroRNAs within Novel Pre-MicroRNAs. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055896
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055896
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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