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Effect of Supplemental Lutein and Zeaxanthin on Serum, Macular Pigmentation, and Visual Performance in Patients with Early Age-Related Macular Degeneration
المؤلفون المشاركون
Huang, Yang-Mu
Dou, Hong-Liang
Huang, Fei-Fei
Xu, Xian-Rong
Zou, Zhi-Yong
Lin, Xiao-Ming
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-01
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Purpose.
To compare the 2-year effect of multiple doses of lutein/zeaxanthin on serum, macular pigmentation, and visual performance on patients with early age-related macular degeneration (AMD).
Methods.
In this randomized, double-blinded, and placebo-controlled trial, 112 early AMD patients randomly received either 10 mg lutein, 20 mg lutein, a combination of lutein (10 mg) and zeaxanthin (10 mg), or placebo daily for 2 years.
Serum concentration of lutein/zeaxanthin, macular pigment optical density (MPOD), visual functions including best-spectacle corrected visual acuity (BCVA), contrast sensitivity (CS), flash recovery time (FRT), and vision-related quality of life (VFQ25) was quantified.
Results.
Serum lutein concentration and MPOD significantly increased in all the active treatment groups.
Supplementation with 20 mg lutein was the most effective in increasing MPOD and CS at 3 cycles/degree for the first 48 weeks.
However, they both significantly increased to the same peak value following supplementation with either 10 mg or 20 mg lutein during the intervention.
No statistical changes of BCVA or FRT were observed during the trial.
Conclusions.
Long-term lutein supplementation could increase serum lutein concentration, MPOD, and visual sensitivities of early AMD patients.
10 mg lutein daily might be an advisable long-term dosage for early AMD treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Yang-Mu& Dou, Hong-Liang& Huang, Fei-Fei& Xu, Xian-Rong& Zou, Zhi-Yong& Lin, Xiao-Ming. 2015. Effect of Supplemental Lutein and Zeaxanthin on Serum, Macular Pigmentation, and Visual Performance in Patients with Early Age-Related Macular Degeneration. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055931
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Yang-Mu…[et al.]. Effect of Supplemental Lutein and Zeaxanthin on Serum, Macular Pigmentation, and Visual Performance in Patients with Early Age-Related Macular Degeneration. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1055931
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Yang-Mu& Dou, Hong-Liang& Huang, Fei-Fei& Xu, Xian-Rong& Zou, Zhi-Yong& Lin, Xiao-Ming. Effect of Supplemental Lutein and Zeaxanthin on Serum, Macular Pigmentation, and Visual Performance in Patients with Early Age-Related Macular Degeneration. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055931
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055931
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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