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Interleukin 16- (IL-16-) Targeted Ultrasound Imaging Agent Improves Detection of Ovarian Tumors in Laying Hens, a Preclinical Model of Spontaneous Ovarian Cancer
المؤلفون المشاركون
Barua, Animesh
Yellapa, Aparna
Bahr, Janice M.
Adur, Malavika K.
Utterback, Chet W.
Bitterman, Pincas
Basu, Sanjib
Sharma, Sameer
Abramowicz, Jacques S.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-16
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Limited resolution of transvaginal ultrasound (TVUS) scanning is a significant barrier to early detection of ovarian cancer (OVCA).
Contrast agents have been suggested to improve the resolution of TVUS scanning.
Emerging evidence suggests that expression of interleukin 16 (IL-16) by the tumor epithelium and microvessels increases in association with OVCA development and offers a potential target for early OVCA detection.
The goal of this study was to examine the feasibility of IL-16-targeted contrast agents in enhancing the intensity of ultrasound imaging from ovarian tumors in hens, a model of spontaneous OVCA.
Contrast agents were developed by conjugating biotinylated anti-IL-16 antibodies with streptavidin coated microbubbles.
Enhancement of ultrasound signal intensity was determined before and after injection of contrast agents.
Following scanning, ovarian tissues were processed for the detection of IL-16 expressing cells and microvessels.
Compared with precontrast, contrast imaging enhanced ultrasound signal intensity significantly in OVCA hens at early ( P < 0.05 ) and late stages ( P < 0.001 ) .
Higher intensities of ultrasound signals in OVCA hens were associated with increased frequencies of IL-16 expressing cells and microvessels.
These results suggest that IL-16-targeted contrast agents improve the visualization of ovarian tumors.
The laying hen may be a suitable model to test new imaging agents and develop targeted anti-OVCA therapeutics.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Barua, Animesh& Yellapa, Aparna& Bahr, Janice M.& Adur, Malavika K.& Utterback, Chet W.& Bitterman, Pincas…[et al.]. 2015. Interleukin 16- (IL-16-) Targeted Ultrasound Imaging Agent Improves Detection of Ovarian Tumors in Laying Hens, a Preclinical Model of Spontaneous Ovarian Cancer. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055934
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Barua, Animesh…[et al.]. Interleukin 16- (IL-16-) Targeted Ultrasound Imaging Agent Improves Detection of Ovarian Tumors in Laying Hens, a Preclinical Model of Spontaneous Ovarian Cancer. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1055934
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Barua, Animesh& Yellapa, Aparna& Bahr, Janice M.& Adur, Malavika K.& Utterback, Chet W.& Bitterman, Pincas…[et al.]. Interleukin 16- (IL-16-) Targeted Ultrasound Imaging Agent Improves Detection of Ovarian Tumors in Laying Hens, a Preclinical Model of Spontaneous Ovarian Cancer. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055934
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055934
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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