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Clostridium butyricum Combined with Bifidobacterium infantis Probiotic Mixture Restores Fecal Microbiota and Attenuates Systemic Inflammation in Mice with Antibiotic-Associated Diarrhea
المؤلفون المشاركون
Ling, Zongxin
Liu, Xia
Cheng, Yiwen
Luo, Yueqiu
Yuan, Li
Li, Lanjuan
Xiang, Charlie
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-23
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Antibiotic-associated diarrhea (AAD) is one of the most common complications of most types of antibiotics.
Our aim was to determine the efficacy of Clostridium butyricum, Bifidobacterium infantis, and their mixture for AAD treatment in mice.
AAD models were administered with single probiotic strain and probiotic mixture for short term and long term to evaluate the changes of the composition and diversity of intestinal microbiota, histopathology of the colon, and the systemic inflammation.
Our data indicated that long-term probiotic therapy, but not short-term course, exerted beneficial effects on the restoration of the intestinal microbiota, the recovery of the tissue architecture, and attenuation of systemic inflammation.
All predominant fecal bacteria reached normal level after the long-term probiotic mixture treatment, while IL-10, IFN-γ, and TNF-α also returned to normal level.
However, the efficacy for AAD was time dependent and probiotic strain specific.
Short-term administration of probiotic strains or mixture showed no apparent positive effects for AAD.
In addition, the beneficial effects of C.
butyricum combined with B.
infantis probiotic mixture were superior to their single strain.
This research showed that supplementation with C.
butyricum combined with B.
infantis probiotic mixture may be a simple and effective method for AAD treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ling, Zongxin& Liu, Xia& Cheng, Yiwen& Luo, Yueqiu& Yuan, Li& Li, Lanjuan…[et al.]. 2015. Clostridium butyricum Combined with Bifidobacterium infantis Probiotic Mixture Restores Fecal Microbiota and Attenuates Systemic Inflammation in Mice with Antibiotic-Associated Diarrhea. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055999
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ling, Zongxin…[et al.]. Clostridium butyricum Combined with Bifidobacterium infantis Probiotic Mixture Restores Fecal Microbiota and Attenuates Systemic Inflammation in Mice with Antibiotic-Associated Diarrhea. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1055999
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ling, Zongxin& Liu, Xia& Cheng, Yiwen& Luo, Yueqiu& Yuan, Li& Li, Lanjuan…[et al.]. Clostridium butyricum Combined with Bifidobacterium infantis Probiotic Mixture Restores Fecal Microbiota and Attenuates Systemic Inflammation in Mice with Antibiotic-Associated Diarrhea. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055999
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1055999
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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