![](/images/graphics-bg.png)
Precuneus and Cingulate Cortex Atrophy and Hypometabolism in Patients with Alzheimer’s Disease and Mild Cognitive Impairment: MRI and 18F-FDG PET Quantitative Analysis Using FreeSurfer
المؤلفون المشاركون
Bailly, Matthieu
Destrieux, Christophe
Hommet, Caroline
Mondon, Karl
Cottier, Jean-Philippe
Beaufils, Emilie
Vierron, Emilie
Vercouillie, Johnny
Ibazizene, Méziane
Voisin, Thierry
Payoux, Pierre
Barré, Louisa
Camus, Vincent
Guilloteau, Denis
Ribeiro, Maria-Joao
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-17
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
The objective of this study was to compare glucose metabolism and atrophy, in the precuneus and cingulate cortex, in patients with Alzheimer’s disease (AD) and mild cognitive impairment (MCI), using FreeSurfer.
Methods.
47 individuals (17 patients with AD, 17 patients with amnestic MCI, and 13 healthy controls (HC)) were included.
MRI and PET images using 18F-FDG (mean injected dose of 185 MBq) were acquired and analyzed using FreeSurfer to define regions of interest in the hippocampus, amygdala, precuneus, and anterior and posterior cingulate cortex.
Regional volumes were generated.
PET images were registered to the T1-weighted MRI images and regional uptake normalized by cerebellum uptake (SUVr) was measured.
Results.
Mean posterior cingulate volume was reduced in MCI and AD.
SUVr were different between the three groups: mean precuneus SUVr was 1.02 for AD, 1.09 for MCI, and 1.26 for controls (p<0.05); mean posterior cingulate SUVr was 0.96, 1.06, and 1.22 for AD, MCI, and controls, respectively (p<0.05).
Conclusion.
We found graduated hypometabolism in the posterior cingulate cortex and the precuneus in prodromal AD (MCI) and AD, whereas atrophy was not significant.
This suggests that the use of 18F-FDG in these two regions could be a neurodegenerative biomarker.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bailly, Matthieu& Destrieux, Christophe& Hommet, Caroline& Mondon, Karl& Cottier, Jean-Philippe& Beaufils, Emilie…[et al.]. 2015. Precuneus and Cingulate Cortex Atrophy and Hypometabolism in Patients with Alzheimer’s Disease and Mild Cognitive Impairment: MRI and 18F-FDG PET Quantitative Analysis Using FreeSurfer. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056007
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bailly, Matthieu…[et al.]. Precuneus and Cingulate Cortex Atrophy and Hypometabolism in Patients with Alzheimer’s Disease and Mild Cognitive Impairment: MRI and 18F-FDG PET Quantitative Analysis Using FreeSurfer. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056007
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bailly, Matthieu& Destrieux, Christophe& Hommet, Caroline& Mondon, Karl& Cottier, Jean-Philippe& Beaufils, Emilie…[et al.]. Precuneus and Cingulate Cortex Atrophy and Hypometabolism in Patients with Alzheimer’s Disease and Mild Cognitive Impairment: MRI and 18F-FDG PET Quantitative Analysis Using FreeSurfer. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056007
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056007
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)