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Sublingual Immunotherapy with a Five-Grass Pollen Tablet in Adult Patients with Allergic Rhinitis: An Open, Prospective, Noninterventional, Multicenter Study
المؤلفون المشاركون
Klimek, Ludger
Pfaar, Oliver
Richter, Heinz-Gerd
Sieber, Jochen
Hadler, Meike
Karagiannis, Efstrathios
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-16
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Although the safety and efficacy of sublingual immunotherapy (SLIT) with a five-grass pollen tablet have been demonstrated in randomized clinical trials (RCTs), these outcomes must always be evaluated in real-life medical practice.
Methods.
In a prospective, open-label, noninterventional, “real-life” study in Germany, we evaluated the safety, tolerability, and effectiveness of SLIT with a five-grass pollen tablet in adults with grass-pollen-induced allergic rhinoconjunctivitis.
Results.
808 adults were enrolled between September 2008 and December 2009.
35.3% of the participants experienced at least one adverse drug reaction (ADR), the most common of which were mild-to-moderate gastrointestinal and respiratory disorders.
Serious ADRs considered causally related to SLIT treatment occurred in four patients.
Overall, the five-grass pollen tablet was considered to have good or very good tolerability by most investigators and patients.
Treatment was associated with the relief of nasal, ocular, and bronchial symptoms and decreased symptomatic medication use.
However, interpretation of clinical improvements was limited by lower atmospheric grass pollen levels during the study season (relative to the preceding season).
Conclusions.
In a large population of patients treated in real-life medical practice, SLIT with a five-grass pollen tablet was safe and well tolerated.
The patient-reported symptom relief suggests that SLIT was associated with clinical benefits.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pfaar, Oliver& Richter, Heinz-Gerd& Klimek, Ludger& Sieber, Jochen& Hadler, Meike& Karagiannis, Efstrathios. 2015. Sublingual Immunotherapy with a Five-Grass Pollen Tablet in Adult Patients with Allergic Rhinitis: An Open, Prospective, Noninterventional, Multicenter Study. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056011
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pfaar, Oliver…[et al.]. Sublingual Immunotherapy with a Five-Grass Pollen Tablet in Adult Patients with Allergic Rhinitis: An Open, Prospective, Noninterventional, Multicenter Study. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1056011
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pfaar, Oliver& Richter, Heinz-Gerd& Klimek, Ludger& Sieber, Jochen& Hadler, Meike& Karagiannis, Efstrathios. Sublingual Immunotherapy with a Five-Grass Pollen Tablet in Adult Patients with Allergic Rhinitis: An Open, Prospective, Noninterventional, Multicenter Study. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056011
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056011
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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