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In Vivo MicroCT Monitoring of Osteomyelitis in a Rat Model
المؤلفون المشاركون
Stadelmann, Vincent A.
Potapova, Inga
Camenisch, Karin
Nehrbass, Dirk
Moriarty, T. Fintan
Richards, R. Geoff
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-29
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Infection associated with orthopedic implants often results in bone loss and requires surgical removal of the implant.
The aim of this study was to evaluate morphological changes of bone adjacent to a bacteria-colonized implant, with the aim of identifying temporal patterns that are characteristic of infection.
In an in vivo study with rats, bone changes were assessed using in vivo microCT at 7 time points during a one-month postoperative period.
The rats received either a sterile or Staphylococcus aureus-colonized polyetheretherketone screw in the tibia.
Bone-implant contact, bone fraction, and bone changes (quiescent, resorbed, and new bone) were calculated from consecutive scans and validated against histomorphometry.
The screw pullout strength was estimated from FE models and the results were validated against mechanical testing.
In the sterile group, bone-implant contact, bone fraction, and mechanical fixation increased steadily until day 14 and then plateaued.
In the infected group, they decreased rapidly.
Bone formation was reduced while resorption was increased, with maximum effects observed within 6 days.
In summary, the model presented is capable of evaluating the patterns of bone changes due to implant-related infections.
The combined use of longitudinal in vivo microCT imaging and image-based finite element analysis provides characteristic signs of infection within 6 days.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Stadelmann, Vincent A.& Potapova, Inga& Camenisch, Karin& Nehrbass, Dirk& Richards, R. Geoff& Moriarty, T. Fintan. 2015. In Vivo MicroCT Monitoring of Osteomyelitis in a Rat Model. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1056025
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Stadelmann, Vincent A.…[et al.]. In Vivo MicroCT Monitoring of Osteomyelitis in a Rat Model. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1056025
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Stadelmann, Vincent A.& Potapova, Inga& Camenisch, Karin& Nehrbass, Dirk& Richards, R. Geoff& Moriarty, T. Fintan. In Vivo MicroCT Monitoring of Osteomyelitis in a Rat Model. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1056025
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1056025
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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